Evidence map›Paper›PMID 28620080›Full record

ArticleJournal of the American Society of Nephrology : JASN2017

The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex.

Shuang Feng, Andrew J Streets, Vasyl Nesin, Uyen Tran, Hongguang Nie, Marta Onopiuk, Oliver Wessely, Leonidas Tsiokas, Albert C M Ong

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Mechanisms ofInternational review of movement disorders · 2021
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Shuang FengKidney Genetics Group, Academic Nephrology Unit and the Bateson Centre, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, United Kingdom.
Andrew J StreetsKidney Genetics Group, Academic Nephrology Unit and the Bateson Centre, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, United Kingdom.
Vasyl NesinDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; and.
Uyen TranDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio.
Hongguang NieDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; and.
Marta OnopiukDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; and.
Oliver WesselyDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio.
Leonidas TsiokasDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; and.
Albert C M OngKidney Genetics Group, Academic Nephrology Unit and the Bateson Centre, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, United Kingdom; a.ong@sheffield.ac.uk.
University of Oklahoma Health Sciences Center · USUniversity of Sheffield · GBCleveland Clinic · US

Funding

Regulation of Ca++ signaling by the PDK 2 gene productR01DK059599 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI TSIOKAS, LEONIDAS · 2002 to 2020
$4.2M
The Role of Bicaudal-C in Polycystic Kidney DiseaseR01DK080745 · NIDDK · LSU HEALTH SCIENCES CENTER · PI WESSELY, OLIVER · 2009 to 2013
$1.7M
Regulation of calcium signaling by the PKD2 gene productR56DK059599 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI TSIOKAS, LEONIDAS · 2010 to 2010
$178k
NIDDK NIH HHS R01 DK059599NIDDK NIH HHS R01 DK080745NIDDK NIH HHS R56 DK059599
6 · The paper itself

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is caused by inactivating mutations in

Indexed as

EndocytosisAnimalsHEK293 CellsHeLa CellsHumansKidney TubulesSorting NexinsTRPP Cation ChannelsVesicular Transport ProteinsXenopusSNX3 protein, humanSorting NexinsTRPP Cation ChannelsVesicular Transport ProteinsVPS35 protein, humanADPKDPKD1PKD2polycystic kidney diseaseretromer

Identifiers

PMID28620080
PMCPMC5619965
OpenAlexW2625862823

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.