ArticleCirculation. Cardiovascular genetics2017
Prediction of Adulthood Obesity Using Genetic and Childhood Clinical Risk Factors in the Cardiovascular Risk in Young Finns Study.
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Article in Circulation. Cardiovascular genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005129 (The Bogalusa Heart Study), which is not on this map. Cited by 24 papers, 3 of them syntheses that pooled it.
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24citing papers in PubMed, 3 pooled it
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Bogalusa Heart Study
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Socioeconomic position, genetic susceptibility, and epigenetic profiles in obesity across the life course: a systematic review.International journal of obesity (2005) · 2026Pooled it
- A Systematic Review on Applications of Artificial Intelligence for Obesity Prevention.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Clinical relevance and validity of tools to predict infant, childhood and adulthood obesity: a systematic review.Public health nutrition · 2018Pooled it
- The RASA2/RASA3 ortholog RasGAP1 modulates obesity-linked phenotypes and is associated with leptin-analog signaling inFrontiers in endocrinology · 2026Article
- Development of Machine Learning-Based Risk Prediction Models to Predict Rapid Weight Gain in Infants: Analysis of Seven Cohorts.JMIR public health and surveillance · 2025Article
- Canine genome-wide association study identifiesScience (New York, N.Y.) · 2025Article
- Harnessing Artificial Intelligence in Obesity Research and Management: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2025Review
- Covariate dependent Markov chains constructed with gradient boost modeling can effectively generate long-term predictions of obesity trends.BMC research notes · 2023Article
- Genomic Innovation in Early Life Cardiovascular Disease Prevention and Treatment.Circulation research · 2023Review
- Applications of Artificial Intelligence to Obesity Research: Scoping Review of Methodologies.Journal of medical Internet research · 2022Article
- The Risk of Atrial Fibrillation Increases with Earlier Onset of Obesity: A Mendelian Randomization Study.International journal of medical sciences · 2022Article
- Healthful plant-based dietary patterns, genetic risk of obesity, and cardiovascular risk in the UK biobank study.Clinical nutrition (Edinburgh, Scotland) · 2021Article
- Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study.Scientific reports · 2021Article
- Prediction for the Risk of Multiple Chronic Conditions Among Working Population in the United States With Machine Learning Models.IEEE open journal of engineering in medicine and biology · 2021Article
- Article
- Longitudinal association of a body mass index (BMI) genetic risk score with growth and BMI changes across the life course: The Cardiovascular Risk in Young Finns Study.International journal of obesity (2005) · 2020Article
- Cardiometabolic-Based Chronic Disease, Adiposity and Dysglycemia Drivers: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2020Review
- Study protocol: The Dutch 20|30 Postmeningitis study: a cross-sectional follow-up of two historical childhood bacterial meningitis cohorts on long-term outcomes.BMC pediatrics · 2019Article
- Genetic risk score predicts risk for overweight and obesity in Finnish preadolescents.Clinical obesity · 2019Article
- Association between Transcription Factor AP-2B genotype, obesity, insulin resistance and dietary intake in a longitudinal birth cohort study.International journal of obesity (2005) · 2019Article
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Authors and funding
12 authors.
Fatemeh SeyednasrollahFrom the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Finland (F.S., J.M., L.L.E.); Department of Mathematics and Statistics (F.S.), Research Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), and Department of Medicine (M.J., J.V.), University of Turku, Finland; Division of Medicine (M.J., J.V.) and Clinical Physiology and Nuclear Medicine (O.T.R.), Turku University Hospital, Finland; Department of Pediatrics (N.H.-K.) and School of Medicine (T.L.), University of Tampere, Finland; Tampere University Hospital, Finland (N.H.-K.); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (T.L.); Tulane University Health Sciences Center, New Orleans, LA (T.K., L.B.); and Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens (C.L.).
Johanna MäkeläFrom the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Finland (F.S., J.M., L.L.E.); Department of Mathematics and Statistics (F.S.), Research Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), and Department of Medicine (M.J., J.V.), University of Turku, Finland; Division of Medicine (M.J., J.V.) and Clinical Physiology and Nuclear Medicine (O.T.R.), Turku University Hospital, Finland; Department of Pediatrics (N.H.-K.) and School of Medicine (T.L.), University of Tampere, Finland; Tampere University Hospital, Finland (N.H.-K.); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (T.L.); Tulane University Health Sciences Center, New Orleans, LA (T.K., L.B.); and Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens (C.L.). jolepp@utu.fi.
Niina PitkänenFrom the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Finland (F.S., J.M., L.L.E.); Department of Mathematics and Statistics (F.S.), Research Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), and Department of Medicine (M.J., J.V.), University of Turku, Finland; Division of Medicine (M.J., J.V.) and Clinical Physiology and Nuclear Medicine (O.T.R.), Turku University Hospital, Finland; Department of Pediatrics (N.H.-K.) and School of Medicine (T.L.), University of Tampere, Finland; Tampere University Hospital, Finland (N.H.-K.); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (T.L.); Tulane University Health Sciences Center, New Orleans, LA (T.K., L.B.); and Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens (C.L.).
Markus JuonalaFrom the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Finland (F.S., J.M., L.L.E.); Department of Mathematics and Statistics (F.S.), Research Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), and Department of Medicine (M.J., J.V.), University of Turku, Finland; Division of Medicine (M.J., J.V.) and Clinical Physiology and Nuclear Medicine (O.T.R.), Turku University Hospital, Finland; Department of Pediatrics (N.H.-K.) and School of Medicine (T.L.), University of Tampere, Finland; Tampere University Hospital, Finland (N.H.-K.); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (T.L.); Tulane University Health Sciences Center, New Orleans, LA (T.K., L.B.); and Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens (C.L.).
Nina Hutri-KähönenFrom the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Finland (F.S., J.M., L.L.E.); Department of Mathematics and Statistics (F.S.), Research Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), and Department of Medicine (M.J., J.V.), University of Turku, Finland; Division of Medicine (M.J., J.V.) and Clinical Physiology and Nuclear Medicine (O.T.R.), Turku University Hospital, Finland; Department of Pediatrics (N.H.-K.) and School of Medicine (T.L.), University of Tampere, Finland; Tampere University Hospital, Finland (N.H.-K.); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (T.L.); Tulane University Health Sciences Center, New Orleans, LA (T.K., L.B.); and Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens (C.L.).
Terho LehtimäkiFrom the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Finland (F.S., J.M., L.L.E.); Department of Mathematics and Statistics (F.S.), Research Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), and Department of Medicine (M.J., J.V.), University of Turku, Finland; Division of Medicine (M.J., J.V.) and Clinical Physiology and Nuclear Medicine (O.T.R.), Turku University Hospital, Finland; Department of Pediatrics (N.H.-K.) and School of Medicine (T.L.), University of Tampere, Finland; Tampere University Hospital, Finland (N.H.-K.); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (T.L.); Tulane University Health Sciences Center, New Orleans, LA (T.K., L.B.); and Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens (C.L.).
Jorma ViikariFrom the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Finland (F.S., J.M., L.L.E.); Department of Mathematics and Statistics (F.S.), Research Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), and Department of Medicine (M.J., J.V.), University of Turku, Finland; Division of Medicine (M.J., J.V.) and Clinical Physiology and Nuclear Medicine (O.T.R.), Turku University Hospital, Finland; Department of Pediatrics (N.H.-K.) and School of Medicine (T.L.), University of Tampere, Finland; Tampere University Hospital, Finland (N.H.-K.); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (T.L.); Tulane University Health Sciences Center, New Orleans, LA (T.K., L.B.); and Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens (C.L.).
Tanika KellyFrom the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Finland (F.S., J.M., L.L.E.); Department of Mathematics and Statistics (F.S.), Research Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), and Department of Medicine (M.J., J.V.), University of Turku, Finland; Division of Medicine (M.J., J.V.) and Clinical Physiology and Nuclear Medicine (O.T.R.), Turku University Hospital, Finland; Department of Pediatrics (N.H.-K.) and School of Medicine (T.L.), University of Tampere, Finland; Tampere University Hospital, Finland (N.H.-K.); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (T.L.); Tulane University Health Sciences Center, New Orleans, LA (T.K., L.B.); and Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens (C.L.).
Changwei LiFrom the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Finland (F.S., J.M., L.L.E.); Department of Mathematics and Statistics (F.S.), Research Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), and Department of Medicine (M.J., J.V.), University of Turku, Finland; Division of Medicine (M.J., J.V.) and Clinical Physiology and Nuclear Medicine (O.T.R.), Turku University Hospital, Finland; Department of Pediatrics (N.H.-K.) and School of Medicine (T.L.), University of Tampere, Finland; Tampere University Hospital, Finland (N.H.-K.); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (T.L.); Tulane University Health Sciences Center, New Orleans, LA (T.K., L.B.); and Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens (C.L.).
Lydia BazzanoFrom the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Finland (F.S., J.M., L.L.E.); Department of Mathematics and Statistics (F.S.), Research Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), and Department of Medicine (M.J., J.V.), University of Turku, Finland; Division of Medicine (M.J., J.V.) and Clinical Physiology and Nuclear Medicine (O.T.R.), Turku University Hospital, Finland; Department of Pediatrics (N.H.-K.) and School of Medicine (T.L.), University of Tampere, Finland; Tampere University Hospital, Finland (N.H.-K.); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (T.L.); Tulane University Health Sciences Center, New Orleans, LA (T.K., L.B.); and Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens (C.L.).
Laura L EloFrom the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Finland (F.S., J.M., L.L.E.); Department of Mathematics and Statistics (F.S.), Research Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), and Department of Medicine (M.J., J.V.), University of Turku, Finland; Division of Medicine (M.J., J.V.) and Clinical Physiology and Nuclear Medicine (O.T.R.), Turku University Hospital, Finland; Department of Pediatrics (N.H.-K.) and School of Medicine (T.L.), University of Tampere, Finland; Tampere University Hospital, Finland (N.H.-K.); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (T.L.); Tulane University Health Sciences Center, New Orleans, LA (T.K., L.B.); and Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens (C.L.).
Olli T RaitakariFrom the Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Finland (F.S., J.M., L.L.E.); Department of Mathematics and Statistics (F.S.), Research Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), and Department of Medicine (M.J., J.V.), University of Turku, Finland; Division of Medicine (M.J., J.V.) and Clinical Physiology and Nuclear Medicine (O.T.R.), Turku University Hospital, Finland; Department of Pediatrics (N.H.-K.) and School of Medicine (T.L.), University of Tampere, Finland; Tampere University Hospital, Finland (N.H.-K.); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (T.L.); Tulane University Health Sciences Center, New Orleans, LA (T.K., L.B.); and Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens (C.L.).
Funding
Lifespan Cardiovascular Risk Exposures and Alzheimer-related brain health: Bogalusa Heart StudyRF1AG041200 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2019 to 2022
$4.2MThe Role of Vascular Aging in Cognitive and Physical Function - Diversity SupplementR01AG041200 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA · 2012 to 2017
$2.9MNIA NIH HHS R01 AG041200NIA NIH HHS RF1 AG041200
Abstract
backgroundObesity is a known risk factor for cardiovascular disease. Early prediction of obesity is essential for prevention. The aim of this study is to assess the use of childhood clinical factors and the genetic risk factors in predicting adulthood obesity using machine learning methods. METHODS AND
resultsA total of 2262 participants from the Cardiovascular Risk in YFS (Young Finns Study) were followed up from childhood (age 3-18 years) to adulthood for 31 years. The data were divided into training (n=1625) and validation (n=637) set. The effect of known genetic risk factors (97 single-nucleotide polymorphisms) was investigated as a weighted genetic risk score of all 97 single-nucleotide polymorphisms (WGRS97) or a subset of 19 most significant single-nucleotide polymorphisms (WGRS19) using boosting machine learning technique. WGRS97 and WGRS19 were validated using external data (n=369) from BHS (Bogalusa Heart Study). WGRS19 improved the accuracy of predicting adulthood obesity in training (area under the curve [AUC=0.787 versus AUC=0.744,
conclusionsWGRS19 improves prediction of adulthood obesity. Predictive accuracy is highest among young children (3-6 years), whereas among older children (9-18 years) the risk can be identified using childhood clinical factors. The model is helpful in screening children with high risk of developing obesity.
Indexed as
AdolescentAdultArea Under CurveBody Mass IndexCarrier ProteinsChildChild, PreschoolC-Reactive ProteinFemaleFinlandFollow-Up StudiesHumansLogistic ModelsMachine LearningMaleMAP Kinase Kinase 5Carrier ProteinsC-Reactive ProteinMAP2K5 protein, humanMAP Kinase Kinase 5POC5 protein, humanTFAP2B protein, humanTranscription Factor AP-2geneticsmachine learningobesityrisk factorsingle-nucleotide polymorphism geneticsstatistics
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NCT00005129ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.