ArticleThe Journal of biological chemistry2017
The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of
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In one paragraph
Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Vitamin C potentiates the killing ofmBio · 2025Article
- Functions of nitroreductases in mycobacterial physiology and drug susceptibility.Journal of bacteriology · 2025Review
- Regulation of oxidative stress response and antioxidant modification in Corynebacterium glutamicum.World journal of microbiology & biotechnology · 2024Review
- Characterization of oxidative stress-induced cgahp, a gene coding for alkyl hydroperoxide reductase, from industrial importance Corynebacterium glutamicum.Biotechnology letters · 2023Review
- SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression.Nucleic acids research · 2023Article
- Machine Learning Models forMolecular pharmaceutics · 2022Article
- Transcriptional regulation and drug resistance inFrontiers in cellular and infection microbiology · 2022Review
- Article
- A novel mycothiol-dependent thiol-disulfide reductase in3 Biotech · 2021Article
- Antitubercular Triazines: Optimization and Intrabacterial Metabolism.Cell chemical biology · 2020Article
- Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activity AgainstFrontiers in cellular and infection microbiology · 2020Article
- Rv0579 Is Involved in the Resistance to the TP053 Antitubercular Prodrug.Frontiers in microbiology · 2020Article
- Mycoredoxins Are Required for Redox Homeostasis and Intracellular Survival in the Actinobacterial PathogenAntioxidants (Basel, Switzerland) · 2019Article
- Assessing the role of Rv1222 (RseA) as an anti-sigma factor of the Mycobacterium tuberculosis extracytoplasmic sigma factor SigE.Scientific reports · 2019Article
- Reactive species and pathogen antioxidant networks during phagocytosis.The Journal of experimental medicine · 2019Review
- Redox regulation by reversible protein S-thiolation in Gram-positive bacteria.Redox biology · 2019Review
- Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.ACS infectious diseases · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 9 institutions in 5 countries.
Leonardo Astolfi RosadoFrom the Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), B-1050 Brussels, Belgium.ORCID 0000-0002-4349-0244
Khadija WahniFrom the Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), B-1050 Brussels, Belgium.
Giulia Degiacomithe Departments of Molecular Medicine and.
Brandán PedreFrom the Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), B-1050 Brussels, Belgium.
David YoungFrom the Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), B-1050 Brussels, Belgium.
Alfonso G de la Rubiathe Department of Molecular Biology, Area of Microbiology, University of León, 24071 León, Spain.
Francesca Boldrinthe Departments of Molecular Medicine and.
Edo MartensFrom the Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), B-1050 Brussels, Belgium.
Laura Marcos-Pascualthe Department of Molecular Biology, Area of Microbiology, University of León, 24071 León, Spain.
Enea Sancho-Vaellothe Unidad de Biofísica, Centro Mixto Consejo Superior de Investigaciones Científicas, Universidad del País Vasco/Euskal Herriko Unibertsitatea (CSIC, UPV/EHU), Barrio Sarriena s/n, Leioa, Bizkaia 48940, Spain.
David Albesa-Jovéthe Unidad de Biofísica, Centro Mixto Consejo Superior de Investigaciones Científicas, Universidad del País Vasco/Euskal Herriko Unibertsitatea (CSIC, UPV/EHU), Barrio Sarriena s/n, Leioa, Bizkaia 48940, Spain.
Roberta ProvvediBiology, University of Padova, 35121 Padova, Italy.
Charlotte Martinthe Research Group of Organic Chemistry, Vrije Universiteit Brussel, B-1050 Brussels, Belgium.
Vadim Makarovthe A. N. Bakh Institute of Biochemistry, Russian Academy of Sciences, 119071 Moscow, Russia.
Wim VerséesFrom the Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), B-1050 Brussels, Belgium.
Guido Verniestthe Research Group of Organic Chemistry, Vrije Universiteit Brussel, B-1050 Brussels, Belgium.
Marcelo E Guerinthe Unidad de Biofísica, Centro Mixto Consejo Superior de Investigaciones Científicas, Universidad del País Vasco/Euskal Herriko Unibertsitatea (CSIC, UPV/EHU), Barrio Sarriena s/n, Leioa, Bizkaia 48940, Spain.
Luis M Mateosthe Department of Molecular Biology, Area of Microbiology, University of León, 24071 León, Spain.
Riccardo Manganellithe Departments of Molecular Medicine and riccardo.manganelli@unipd.it.
Joris MessensFrom the Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), B-1050 Brussels, Belgium, joris.messens@vib-vub.be.ORCID 0000-0002-2128-8264
Vlaams Instituut voor Biotechnologie · BEInstitute of Molecular Medicine · INUniversidad de León · ESVIB-VUB Center for Structural Biology · BEConsejo Superior de Investigaciones Científicas · ESVrije Universiteit Brussel · BEA N Bach Institute of Biochemistry · RUUniversity of Padua · ITUniversity of the Basque Country · ES
Funding
No grant is acknowledged in the PubMed record.
Abstract
The
Indexed as
Models, MolecularActivation, MetabolicAnti-Bacterial AgentsBacterial ProteinsBiocatalysisCatalytic DomainCrystallography, X-RayCysteineDisk Diffusion Antimicrobial TestsDrugs, InvestigationalGene DeletionMolecular ConformationMolecular Docking SimulationMycobacterium tuberculosisOxidation-ReductionOxidative StressAnti-Bacterial AgentsBacterial ProteinsCysteineDrugs, InvestigationalProdrugsProtein Disulfide-IsomerasesPyrimidinesRecombinant Proteinsenzyme catalysisMycobacterium tuberculosisoxidation-reduction (redox)oxidative stressoxidoreductasephylogeneticsthiol–disulfide exchange
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.