Evidence map›Paper›PMID 28620006›Full record

ReviewClinical cancer research : an official journal of the American Association for Cancer Research2017

Cancer Surveillance in Gorlin Syndrome and Rhabdoid Tumor Predisposition Syndrome.

William D Foulkes, Junne Kamihara, D Gareth R Evans, Laurence Brugières, Franck Bourdeaut, Jan J Molenaar, Michael F Walsh, Garrett M Brodeur, Lisa Diller

Open access · bronzeAbstract readReview
In one paragraph

Review in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 1 synthesis or guideline pooled it, 185 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Pediatric Cancer Predisposition and Surveillance Update: Summary Perspective and Future Directions.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Review
  12. Article
  13. Article
  14. Germline Variants in Pediatric Cancer : Based on Oncogenic Pathways.Journal of Korean Neurosurgical Society · 2025
    Article
  15. Review
  16. Article
  17. Update on Cancer Predisposition Syndromes and Surveillance Guidelines for Childhood Brain Tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Review
  18. Review
  19. Genetic Predisposition to Sarcoma: What Should Clinicians Know?Current treatment options in oncology · 2024
    Review
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

William D FoulkesDepartments of Human Genetics, Medicine and Oncology, McGill University, Montreal, Québec, Canada.
Junne KamiharaDana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, Massachusetts.
D Gareth R EvansDivision of Evolution and Genomic Science, Department of Genomic Medicine, MAHSC, University of Manchester, Saint Mary's Hospital, Manchester, England.
Laurence BrugièresChild and Adolescent Cancer Department, Gustave Roussy Institute, Villejuif, France.
Franck BourdeautInstitut Curie, Integrated Cancer Research Site, Paris, France.
Jan J MolenaarPrincess Máxima Center for Pediatric Oncology, Amsterdam, the Netherlands.
Michael F WalshMemorial Sloan Kettering Cancer Center, New York, New York.
Garrett M BrodeurChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Lisa DillerDana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, Massachusetts. Lisa_Diller@dfci.harvard.edu.
Kettering University · US

Funding

Pediatric Scholars ProgramK12HD043245 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ST. GEME, JOSEPH W. · 2003 to 2022
$7.4M
NICHD NIH HHS K12 HD043245
6 · The paper itself

Abstract

Gorlin syndrome and rhabdoid tumor predisposition syndrome (RTPS) are autosomal dominant syndromes associated with an increased risk of childhood-onset brain tumors. Individuals with Gorlin syndrome can manifest a wide range of phenotypic abnormalities, with about 5% of family members developing medulloblastoma, usually occurring in the first 3 years of life. Gorlin syndrome is associated with germline mutations in components of the Sonic Hedgehog pathway, including Patched1 (

Indexed as

Basal Cell Nevus SyndromeBrain NeoplasmsChild, PreschoolChromatin Assembly and DisassemblyDNA HelicasesGerm-Line MutationHumansInfantKidney NeoplasmsNuclear ProteinsPatched-1 ReceptorRepressor ProteinsRhabdoid TumorSMARCB1 ProteinTranscription FactorsDNA HelicasesNuclear ProteinsPatched-1 ReceptorPTCH1 protein, humanRepressor ProteinsSMARCA4 protein, humanSMARCB1 ProteinSMARCB1 protein, humanSUFU protein, humanTranscription Factors

Identifiers

PMID28620006
PMCPMC7309678
OpenAlexW2726357279

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.