Evidence map›Paper›PMID 28619820›Full record

ArticleDevelopment (Cambridge, England)2017

SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development.

Ivy Kim-Ni Chiang, Martin Fritzsche, Cathy Pichol-Thievend, Alice Neal, Kelly Holmes, Anne Lagendijk, Jeroen Overman, Donatella D'Angelo, Alice Omini, Dorien Hermkens and 12 more

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Dissecting endothelial cell heterogeneity with new tools.Cell regeneration (London, England) · 2025
    Review
  6. Article
  7. Review
  8. Endothelial cell transitions in zebrafish vascular development.Development, growth & differentiation · 2024
    Review
  9. Article
  10. Article
  11. Transcription factors regulating vasculogenesis and angiogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2024
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Notch Signaling in Acute Inflammation and Sepsis.International journal of molecular sciences · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 5 countries.

Ivy Kim-Ni ChiangInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Martin FritzscheLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, The University of Oxford, Oxford OX3 7DQ, UK.
Cathy Pichol-ThievendInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Alice NealLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, The University of Oxford, Oxford OX3 7DQ, UK.
Kelly HolmesCancer Research UK, The University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
Anne LagendijkInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Jeroen OvermanInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Donatella D'AngeloDipartimento di Bioscienze, Universita' degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy.
Alice OminiDipartimento di Bioscienze, Universita' degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy.
Dorien HermkensUniversity of Münster, 48149 Münster, Germany Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, Westfälische Wilhelms-Universität Münster (WWU), Mendelstrasse 7, 48149 Münster and CiM Cluster of Excellence, Germany.
Emmanuelle LesieurInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Ke LiuInstitute of Aging and Chronic Disease, University of Liverpool, Liverpool L69 3GA, UK.
Indrika RatnayakaLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, The University of Oxford, Oxford OX3 7DQ, UK.
Monica CoradaIFOM, FIRC Institute of Molecular Oncology, 1620139 Milan, Italy.
George Bou-GhariosInstitute of Aging and Chronic Disease, University of Liverpool, Liverpool L69 3GA, UK.
Jason CarrollCancer Research UK, The University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
Elisabetta DejanaIFOM, FIRC Institute of Molecular Oncology, 1620139 Milan, Italy.
Stefan Schulte-MerkerUniversity of Münster, 48149 Münster, Germany Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, Westfälische Wilhelms-Universität Münster (WWU), Mendelstrasse 7, 48149 Münster and CiM Cluster of Excellence, Germany.
Benjamin HoganInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Monica BeltrameDipartimento di Bioscienze, Universita' degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy.
Sarah De ValLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, The University of Oxford, Oxford OX3 7DQ, UK sarah.deval@ludwig.ox.ac.uk m.francois@imb.uq.edu.au.
Mathias FrancoisInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia sarah.deval@ludwig.ox.ac.uk m.francois@imb.uq.edu.au.ORCID 0000-0002-9846-6882
The University of Queensland · AUUniversity of Oxford · GBUniversity of Milan · ITUniversity of Cambridge · GBUniversity of Liverpool · GBUniversity of Münster · DEIFOM · ITUppsala University · SE

Funding

Biotechnology and Biological Sciences Research Council BB/L020238/1Cancer Research UK 20411Medical Research Council MR/J007765/1Medical Research Council MR/P020941/1
6 · The paper itself

Abstract

Arterial specification and differentiation are influenced by a number of regulatory pathways. While it is known that the Vegfa-Notch cascade plays a central role, the transcriptional hierarchy controlling arterial specification has not been fully delineated. To elucidate the direct transcriptional regulators of Notch receptor expression in arterial endothelial cells, we used histone signatures, DNaseI hypersensitivity and ChIP-seq data to identify enhancers for the human

Indexed as

Amino Acid SequenceAnimalsAnimals, Genetically ModifiedArteriesArteriovenous MalformationsEnhancer Elements, GeneticFemaleGene Expression Regulation, DevelopmentalHumansHuman Umbilical Vein Endothelial CellsMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPregnancyNotch1b protein, zebrafishNOTCH1 protein, humanNotch1 protein, mouseReceptor, Notch1SOXF Transcription FactorsZebrafish ProteinsArterial enhancerArteryEndothelial cellHumanMouseNotch1SoxFTranscriptional regulationZebrafish

Identifiers

PMID28619820
PMCPMC5536923
OpenAlexW2625982705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.