ArticleBMJ open2017
Early termination of cardiovascular trials as a consequence of poor accrual: analysis of ClinicalTrials.gov 2006-2015.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of enrollment into ARDS and sepsis trials published between 2009 and 2019 in major journals.Critical care (London, England) · 2021Pooled it
- Trends and Predictors of Premature Termination of Cardiovascular Trials: A Systematic Review.JACC. Advances · 2026Article
- Measuring What Matters in Trial Operations: Development and Validation of the Clinical Trial Site Performance Measure.Journal of clinical medicine · 2025Article
- Eligibility of Asian and European registry patients for phase III trials in heart failure with reduced ejection fraction.ESC heart failure · 2024Article
- Views and Perceptions of Amyloid Imaging in a Preclinical Alzheimer's Disease Trial.The journal of prevention of Alzheimer's disease · 2024Article
- Recruitment, Retention, and Participant Diversity in the Context of a Heart Failure Self-Care Digital Intervention Decentralized Clinical Trial.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024Article
- Early Termination of Oncology Clinical Trials in the United States.Cancer medicine · 2023Article
- Recruitment across two decades of NIH-funded Alzheimer's disease clinical trials.Alzheimer's research & therapy · 2023Article
- General characteristics and reasons for the discontinuation of drug clinical trials in mainland China.BMC medical research methodology · 2021Observational
- Handling Poor Accrual in Pediatric Trials: A Simulation Study Using a Bayesian Approach.International journal of environmental research and public health · 2021Article
- Obstacles to the reuse of study metadata in ClinicalTrials.gov.Scientific data · 2020Article
- Pilot test of an accrual Common Metric for the NIH Clinical and Translational Science Awards (CTSA) Consortium: Metric feasibility and data quality.Journal of clinical and translational science · 2020Article
- A multi-state model analysis of the time from ethical approval to publication of clinical research studies.PloS one · 2020Article
- A pilot randomized trial of five financial incentive strategies to increase study enrollment and retention rates.Contemporary clinical trials communications · 2019Article
- Observational
- Pediatric Trials Run in India: An Analysis of Clinical Trials.gov 2006-2015.Indian journal of pediatrics · 2019Review
- Randomized evaluation of trial acceptability by INcentive (RETAIN): Study protocol for two embedded randomized controlled trials.Contemporary clinical trials · 2019Article
- Evolving Landscape of Clinical Trials in Heart Failure: Patient Populations, Endpoint Selection, and Regions of Enrollment.Current heart failure reports · 2018Review
- "I Want to Do It, But I Want to Make Sure That I Do It Right." Views of Patients with Parkinson's Disease Regarding Early Stem Cell Clinical Trial Participation.AJOB empirical bioethicsArticle
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo present a snapshot of experimental cardiovascular research with a focus on geographical and temporal patterns of early termination due to poor accrual.
settingThe Aggregate Analysis of ClinicalTrials.gov (AACT) database, reflecting ClinicalTrials.gov as of 27 March 2016.
designThe AACT database was searched for all cardiovascular clinical trials that started from January 2006 up to December 2015.
resultsThirteen thousand and seven hundred twenty-nine cardiovascular trials were identified. Of these, 8900 (65%) were classified as closed studies. Globally, 11% of closed trials were terminated. This proportion varied from 9.6% to 14% for trials recruiting from Europe and Americas, respectively, with a slightly decreasing trend (p=0.02) over the study period. The most common reason for trials failing to complete was poor accrual (41%). Intercontinental trials exhibited lower figures of poor accrual as the reason for their early stopping, as compared with trials recruiting in a single continent (28% vs 44%, p=0.002).
conclusionsPoor accrual significantly challenges the successful completion of cardiovascular clinical trials. Findings are suggestive of a positive effect of globalisation of cardiovascular clinical research on the achievement of enrolment goals within a reasonable time frame.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.