Evidence map›Paper›PMID 28619735›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2017

The Evolving Role of Succinate in Tumor Metabolism: An

Philippe Garrigue, Aurore Bodin-Hullin, Laure Balasse, Samantha Fernandez, Wassim Essamet, Françoise Dignat-George, Karel Pacak, Benjamin Guillet, David Taïeb

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. Metabolic Subtyping of Pheochromocytoma and Paraganglioma byJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Molecular Imaging in the Era of Precision Medicine: Paraganglioma as a Template for Understanding Multiple Levels of Analysis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020
    Article
  8. Genetic Determinants of Pheochromocytoma and Paraganglioma Imaging Phenotypes.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Diagnostic Investigation of Lesions Associated with Succinate Dehydrogenase Defects.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2019
    Review
  14. Review
  15. Review
  16. TranslatingJCO precision oncology · 2018
    Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Philippe GarrigueAix-Marseille University, INSERM, UMR-S 1076, Marseille, France.
Aurore Bodin-HullinDepartment of Nuclear Medicine, Aix-Marseille University, Marseille, France.
Laure BalasseAix-Marseille University, INSERM, UMR-S 1076, Marseille, France.
Samantha FernandezAix-Marseille University, CERIMED, Marseille, France.
Wassim EssametDepartment of Neuropathology, APHM Timone, Marseille, France; and.
Françoise Dignat-GeorgeAix-Marseille University, INSERM, UMR-S 1076, Marseille, France.
Karel PacakSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland.
Benjamin GuilletAix-Marseille University, INSERM, UMR-S 1076, Marseille, France.
David TaïebAix-Marseille University, CERIMED, Marseille, France david.taieb@ap-hm.fr.
Inserm · FRAix-Marseille Université · FRHôpital de la Timone · FRNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, inherited and acquired mutations in the tricarboxylic acid (TCA) cycle enzymes have been reported in diverse cancers. Pheochromocytomas and paragangliomas often exhibit dysregulation of glucose metabolism, which is also driven by mutations in genes encoding the TCA cycle enzymes or by activation of hypoxia signaling. Pheochromocytomas and paragangliomas associated with succinate dehydrogenase (SDH) deficiency are characterized by high

Indexed as

AnimalsAutoradiographyCell Line, TumorCitric Acid CycleConnective TissueFluorodeoxyglucose F18FumaratesGlucose Transporter Type 1HumansHuman Umbilical Vein Endothelial CellsMiceMice, Inbred BALB CMice, NudeNeoplasmsPositron Emission Tomography Computed TomographyRadiopharmaceuticalsFluorodeoxyglucose F18FumaratesGlucose Transporter Type 1RadiopharmaceuticalsSlc2a1 protein, mouseSuccinates18F-FDGparagangliomasuccinatesuccinate dehydrogenasetricarboxylic acid cycle

Identifiers

PMID28619735
PMCPMC6944169
OpenAlexW2625733077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.