ArticleScience (New York, N.Y.)2017
Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.
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Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers.
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0cells of the map it votes in
173citing papers in PubMed
18.4field-weighted citation impact, top 1% of its field
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Who cites it
173 citing papers in PubMed, 271 citations in OpenAlex.
- High-throughput screening approach identifies substrate-selective Hsp104 variants that counter amyloid seeding with diminished off-target effects.Molecular cell · 2026Article
- A stochastic mechanism drives fast substrate translocation in the AAA+ machine ClpB.Nature communications · 2026Article
- Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers.FEBS letters · 2026Article
- Modeling Protein Aggregation Kinetics from NMR Data.Journal of molecular biology · 2025Review
- Heat Shock Protein 104 (Genes · 2025Article
- Structure of the central Staphylococcus aureus AAA+ protease MecA/ClpC/ClpP.Communications biology · 2025Article
- Elastic analysis bridges structure and dynamics of an AAA+ molecular motor.PLoS computational biology · 2025Article
- Heat Shock Protein and Disaggregase Influencing the Casein Structuralisation.International journal of molecular sciences · 2025Article
- Mapping Hsp104 interactions using cross-linking mass spectrometry.FEBS open bio · 2025Article
- Subunit specialization in AAA+ proteins and substrate unfolding during transcription complex remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Ferguson Plot Analysis of Chaperone ClpB from Moderate Halophile.The protein journal · 2025Article
- Design principles to tailor Hsp104 therapeutics.Cell reports · 2024Article
- eIF5A controls mitoprotein import by relieving ribosome stalling at TIM50 translocase mRNA.The Journal of cell biology · 2024Article
- The middle domain of Hsp104 can ensure substrates are functional after processing.PLoS genetics · 2024Article
- Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway.Nature communications · 2024Article
- Design principles to tailor Hsp104 therapeutics.bioRxiv : the preprint server for biology · 2024Article
- Article
- Nuclear Hsp104 safeguards the dormant translation machinery during quiescence.Nature communications · 2024Article
- The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.Nature structural & molecular biology · 2023Article
- Structural insights of the p97/VCP AAA+ ATPase: How adapter interactions coordinate diverse cellular functionality.The Journal of biological chemistry · 2023Review
113 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Stephanie N GatesDepartment of Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4312-2900
Adam L YokomDepartment of Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3746-7961
JiaBei LinDepartment of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-8863-1859
Meredith E JackrelDepartment of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-4406-9504
Alexandrea N RizoGraduate Program in Chemical Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-4813-6348
Nathan M KendserskyDepartment of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-0132-8748
Courtney E BuellDepartment of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-3493-7681
Elizabeth A SweenyDepartment of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-7818-9112
Korrie L MackDepartment of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7678-146X
Edward ChuangDepartment of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-6380-7317
Mariana P TorrenteDepartment of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-8220-2228
Min SuDepartment of Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-0561-906X
James ShorterDepartment of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-5269-8533
Daniel R SouthworthDepartment of Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA. dsouth@umich.edu.ORCID 0000-0001-7108-9389
University of Pennsylvania · USUniversity of Michigan · USThe Graduate Center, CUNY · US
Funding
University of Pennsylvania Postdoctoral Opportunities in Research and TeachingK12GM081259 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Janis K. Burkhardt · 2007 to 2026
$20.1MPREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM008076 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A · 1985 to 2023
$10.8MP450 and NO Synthase Regulation by Multiprotein ComplexesR01GM077430 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OSAWA, YOICHI, ZHANG, HAOMING · 2006 to 2022
$6.5MSTRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008275 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WAND, A. JOSHUA · 1988 to 2018
$6.0MMICHIGAN CHEMISTRY-BIOLOGY INTERFACE TRAINING PROGRAMT32GM008597 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MONTGOMERY, JOHN · 1996 to 2018
$5.0MDefining the mechanistic basis of a prion disaggregaseR01GM099836 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SHORTER, JAMES · 2013 to 2024
$3.9MDefining the conformational cycle of nitric oxide synthasesR01GM110001 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SOUTHWORTH, DANIEL RYLAND · 2015 to 2019
$1.5MExploration of Molecular Chaperone Complexes During Active Protein TriageR01GM109896 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREWS, PHILIP C, GESTWICKI, JASON E · 2014 to 2017
$1.1MEpigenetics In Neurodegenerative Disease: Targeting Histone Modifications in ALSK22NS091314 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TORRENTE, MARIANA PLAZAS · 2015 to 2017
$536kSilicon Mechanics Compute ClusterS10OD020011 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SKINIOTIS, GEORGIOS · 2015 to 2015
$490kNIGMS NIH HHS K12 GM081259NIGMS NIH HHS R01 GM077430NIGMS NIH HHS R01 GM099836NIGMS NIH HHS R01 GM109896NIGMS NIH HHS R01 GM110001NIGMS NIH HHS T32 GM008076NIGMS NIH HHS T32 GM008275NIGMS NIH HHS T32 GM008597NIH HHS S10 OD020011NINDS NIH HHS K22 NS091314
Abstract
Hsp100 polypeptide translocases are conserved members of the AAA+ family (adenosine triphosphatases associated with diverse cellular activities) that maintain proteostasis by unfolding aberrant and toxic proteins for refolding or proteolytic degradation. The Hsp104 disaggregase from
Indexed as
CaseinsCryoelectron MicroscopyHeat-Shock ProteinsHydrolysisNucleotidesPeptidesPromoter Regions, GeneticProtein DomainsProtein TransportSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSubstrate SpecificityTyrosineCaseinsHeat-Shock ProteinsHsP104 protein, S cerevisiaeNucleotidesPeptidesSaccharomyces cerevisiae ProteinsTyrosine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.