Observational studyPediatric neurology2017
Cumulative Incidence of Seizures and Epilepsy in Ten-Year-Old Children Born Before 28 Weeks' Gestation.
Observational study in Pediatric neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- Neonatal inflammation predicts adolescent brain volume and neurologic outcomes in children born extremely prematurely.Scientific reports · 2026Article
- Retinopathy of Prematurity and Neurodevelopmental and Quality-of-Life Outcomes at 10 Years of Age.American journal of perinatology · 2026Article
- Extremely/Very Premature Birth Associated With Focal Epileptic Activity in Comorbid Autism and Epilepsy.Journal of child neurology · 2026Article
- Risk factors and neurodevelopmental outcomes of post-neonatal seizures up to age three in very-low-birthweight infants based on a nationwide cohort.Scientific reports · 2025Article
- Count of Neonatal Morbidities Predicts Outcomes at Age 10 and 15 Years in Infants Born Extremely Preterm.The Journal of pediatrics · 2025Article
- Epilepsy in Cerebral Palsy: Unraveling Prevalence, Risk Factors, and Subtype Associations in a Large-Scale Population Study.Medicina (Kaunas, Lithuania) · 2024Article
- Retinopathy of prematurity and neurodevelopmental outcome and quality of life at 10 years of age.Research square · 2024Article
- Social determinants of health rather than race impact health-related quality of life in 10-year-old children born extremely preterm.Frontiers in pediatrics · 2024Article
- Environmental influences on child health outcomes: cohorts of individuals born very preterm.Pediatric research · 2023Review
- Comparing autism phenotypes in children born extremely preterm and born at term.Autism research : official journal of the International Society for Autism Research · 2023Article
- Quantitative MRI Characterization of the Extremely Preterm Brain at Adolescence: Atypical versus Neurotypical Developmental Pathways.Radiology · 2022Article
- Psychiatric Outcomes, Functioning, and Participation in Extremely Low Gestational Age Newborns at Age 15 Years.Journal of the American Academy of Child and Adolescent Psychiatry · 2022Article
- Perinatal adversities and risk of epilepsy after traumatic brain injury: A Danish nationwide cohort study.Acta neurologica Scandinavica · 2022Article
- Extreme prematurity: Risk and resiliency.Current problems in pediatric and adolescent health care · 2022Review
- Neonatal Cranial Ultrasound Findings among Infants Born Extremely Preterm: Associations with Neurodevelopmental Outcomes at 10 Years of Age.The Journal of pediatrics · 2021Article
- Changes in Neurodevelopmental Outcomes From Age 2 to 10 Years for Children Born Extremely Preterm.Pediatrics · 2021Article
- Anxiety and Depression Correlates at Age 10 in Children Born Extremely Preterm.Journal of pediatric psychology · 2021Article
- Histologic chorioamnionitis and risk of neurodevelopmental impairment at age 10 years among extremely preterm infants born before 28 weeks of gestation.American journal of obstetrics and gynecology · 2020Observational
- Seizure prevalence in children aged up to 3 years: a longitudinal population-based cohort study in Japan.BMJ open · 2020Article
- Evaluation of Risk Factors for Epilepsy in Pediatric Patients with Cerebral Palsy.Brain sciences · 2020Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveWe evaluated the incidence of seizures and epilepsy in the first decade of life among children born extremely premature (less than 28 weeks' gestation).
methodIn a prospective, multicenter, observational study, 889 of 966 eligible children born in 2002 to 2004 were evaluated at two and ten years for neurological morbidity. Complementing questionnaire data to determine a history of seizures, all caregivers were interviewed retrospectively for postneonatal seizures using a validated seizure screen followed by a structured clinical interview by a pediatric epileptologist. A second pediatric epileptologist established an independent diagnosis based on recorded responses of the interview. A third epileptologist determined the final diagnosis when evaluators disagreed (3%). Life table survival methods were used to estimate seizure incidence through ten years.
resultsBy age ten years, 12.2% (95% confidence interval: 9.8, 14.5) of children had experienced one or more seizures, 7.6% (95% confidence interval: 5.7, 9.5) had epilepsy, 3.2% had seizure with fever, and 1.3% had a single, unprovoked seizure. The seizure incidence increased with decreasing gestational age. In more than 75% of children with seizures, onset was after one year of age. Seizure incidence was comparable in both sexes. Two-thirds of those with epilepsy had other neurological disorders. One third of children with epilepsy were not recorded on the medical history questionnaire. SIGNIFICANCE: The incidence of epilepsy through age ten years among children born extremely premature is approximately 7- to 14-fold higher than the 0.5% to 1% lifetime incidence reported in the general pediatric population. Seizures in this population are under-recognized, and possibly underdiagnosed, by parents and providers.
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