Evidence map›Paper›PMID 28619367›Full record

ReviewPharmacological research2017

The vasoprotective axes of the renin-angiotensin system: Physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases.

Xiao C Li, Jianfeng Zhang, Jia L Zhuo

Registry-linked trialAbstract readReview
In one paragraph

Review in Pharmacological research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05299346 (Post-ICU Covid19 Follow-up With Regards to Lung, Heart, Kidney and Cognitive Function), which is not on this map. Cited by 210 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
210citing papers in PubMed, 7 pooled it
38.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05299346 completednot on this mapstarted 2020, after this paper: background citation

Post-ICU Covid19 Follow-up With Regards to Lung, Heart, Kidney and Cognitive Function

Typeobservational_patient_registrySponsorSahlgrenska University HospitalRan2020 to 2023Enrolled793ConditionsCOVID-19 Pandemic, Intensive Care Unit Syndrome, DeliriumArmsFollow up
3 · Its place in the literature

Who cites it

210 citing papers in PubMed, 7 syntheses or guidelines pooled it, 447 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Impact of Cardiovascular Diseases on COVID-19: A Systematic Review.Medical science monitor : international medical journal of experimental and clinical research · 2021
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Guideline
  8. Trial
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Effects of Air Conditioning-Induced Humidity Reduction on Glomerular Filtration Rate in Healthy Adults.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  15. Article
  16. Article
  17. Diagnostic Value of Let-7a-5p in Essential Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2025
    Article
  18. Article
  19. Deletion of ATAmerican journal of physiology. Renal physiology · 2024
    Article
  20. Article

150 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Xiao C LiLaboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA.
Jianfeng ZhangDepartment of Emergency Medicine, The 2nd Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
Jia L ZhuoLaboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA. Electronic address: jzhuo@umc.edu.
University of Mississippi Medical Center · USGuangxi Medical University · CN

Funding

Role of Intracrine Angiotensin II in Kidney CellsR01DK067299 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI Jia Long Zhuo · 2004 to 2026
$6.5M
Role of Proximal Tubule NHE3 in Angiotensin II-induced HypertensionR01DK102429 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZHUO, JIA LONG · 2014 to 2021
$2.5M
The Na+/H+ Exchanger 3, Pressure Natriuresis, and HypertensionR56HL130988 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZHUO, JIA LONG · 2016 to 2016
$381k
Novel Roles of Intracrine Angiotensin II in Proximal Tubule CellsR56DK067299 · NIDDK · HENRY FORD HEALTH SYSTEM · PI ZHUO, JIA LONG · 2009 to 2009
$352k
NHLBI NIH HHS R56 HL130988NIDDK NIH HHS R01 DK067299NIDDK NIH HHS R01 DK102429NIDDK NIH HHS R56 DK067299
6 · The paper itself

Abstract

The renin-angiotensin system (RAS) is undisputedly one of the most prominent endocrine (tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) vasoactive systems in the physiological regulation of neural, cardiovascular, blood pressure, and kidney function. The importance of the RAS in the development and pathogenesis of cardiovascular, hypertensive and kidney diseases has now been firmly established in clinical trials and practice using renin inhibitors, angiotensin-converting enzyme (ACE) inhibitors, type 1 (AT

Indexed as

AnimalsCardiovascular DiseasesHumansHypertensionKidney DiseasesRenin-Angiotensin SystemSignal TransductionACE2AlamandineAngioprotectinAngiotensin (1–7)Angiotensin 1-converting enzymeAngiotensin IICardiovascular diseaseDipeptidyl peptidase IIIHypertension

Identifiers

PMID28619367
PMCPMC5607101
OpenAlexW2625441704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.