ArticleJournal of physiological anthropology2017
Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels.
Article in Journal of physiological anthropology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 30 citations in OpenAlex.
- Estimating genetic correlation jointly using individual-level and summary-level GWAS data.Nature communications · 2026Article
- Error-controlled non-additive interaction discovery in machine learning models.Nature machine intelligence · 2025Article
- Correlates of normal and decreased HDL cholesterol levels in type 2 diabetes: a cohort-based cross-sectional study.Lipids in health and disease · 2024Article
- Association between smoking and height loss in Japanese workers: A retrospective study.PloS one · 2024Article
- Observational
- Mechanism underlying vascular remodeling in relation to circulating CD34-positive cells among older Japanese men.Scientific reports · 2022Article
- Associations between the lipid profile and the development of hypertension in young individuals - the preliminary study.Archives of medical science : AMS · 2022Article
- Associations between handgrip strength and hypertension in relation to circulating CD34-positive cell levels among Japanese older men: a cross-sectional study.Environmental health and preventive medicine · 2021Article
- Cross-sectional study of prevalence and determinants of uncontrolled hypertension among South African adult residents of Mkhondo municipality.BMC public health · 2020Article
- Gamma-glutamyl transpeptidase (γ-GTP) has an ambivalent association with hypertension and atherosclerosis among elderly Japanese men: a cross-sectional study.Environmental health and preventive medicine · 2019Article
- Short stature-related single-nucleotide polymorphism (SNP) activates endothelial repair activity in elderly Japanese.Environmental health and preventive medicine · 2019Article
- Article
- Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study.Clinical interventions in aging · 2019Article
- Association between tongue pressure and subclinical carotid atherosclerosis in relation to platelet levels in hypertensive elderly men: a cross-sectional study.Environmental health and preventive medicine · 2018Article
- Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels.Environmental health and preventive medicine · 2018Article
- Triglycerides and blood pressure in relation to circulating CD34-positive cell levels among community-dwelling elderly Japanese men: a cross-sectional study.Environmental health and preventive medicine · 2017Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough high-density lipoprotein-cholesterol (HDL) level is inversely correlated with cardiovascular events, HDL is also reported to be positively associated with hypertension, which is a known endothelial impairment factor. Since HDL mediates important protective actions on the vascular endothelium by increasing the number of circulating endothelial progenitor cells (CD34-positive cells), the level of circulating CD34-positive cells should influence the association between HDL and hypertension.
methodsTo investigate the association between HDL and hypertension in relation to the level of circulating CD34-positive cells, we conducted a cross-sectional study of 477 elderly men aged 60-69 years who participated in general health checkup.
resultsHDL was found to be significantly positively associated with hypertension in subjects with a high level of circulating CD34-positive cells, while no significant association was observed for subjects with low circulating CD34-positive cells. Known cardiovascular risk factors adjusted odds (ORs) and 95% confidence intervals (CIs) of hypertension for increments of one standard deviation (SD) in HDL (13.8 mg/dL) were 1.44 (1.06, 1.96) for subjects with a high level of circulating CD34-positive cells and 0.87 (0.63, 1.19) for subjects with low circulating CD34-positive cells. We also revealed a significant association between HDL level and CD34-positive cell level on hypertension, with fully adjusted p values for the effect of this interaction on hypertension at 0.022.
conclusionsIndependent of known cardiovascular risk factors, HDL was found to be positively associated with hypertension in subjects with a high level of circulating CD34-positive cells but not for subjects with low circulating CD34-positive cells.
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