Evidence map›Paper›PMID 28619032›Full record

ArticleJournal of nanobiotechnology2017

The role of intracellular trafficking of CdSe/ZnS QDs on their consequent toxicity profile.

Bella B Manshian, Thomas F Martens, Karsten Kantner, Kevin Braeckmans, Stefaan C De Smedt, Jo Demeester, Gareth J S Jenkins, Wolfgang J Parak, Beatriz Pelaz, Shareen H Doak and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
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  3. Review
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  7. Review
  8. Exocytosis of Nanoparticles: A Comprehensive Review.Nanomaterials (Basel, Switzerland) · 2023
    Review
  9. Article
  10. Current applications of nanomaterials in urinary system tumors.Frontiers in bioengineering and biotechnology · 2023
    Review
  11. Article
  12. A Review of in vivo Toxicity of Quantum Dots in Animal Models.International journal of nanomedicine · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Bella B ManshianBiomedical NMR Unit/MoSAIC, KU Leuven Campus Gasthuisberg, Herestraat 49, 3000, Louvain, Belgium. bella.manshian@kuleuven.be.ORCID http://orcid.org/0000-0002-3402-3927
Thomas F MartensFaculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000, Ghent, Belgium.
Karsten KantnerPhilipps University of Marburg, Renthof 7, 35032, Marburg, Germany.
Kevin BraeckmansFaculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000, Ghent, Belgium.
Stefaan C De SmedtFaculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000, Ghent, Belgium.
Jo DemeesterFaculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000, Ghent, Belgium.
Gareth J S JenkinsInstitute of Life Science, Swansea University Medical School, Singleton Park, Swansea, SA2 8PP, UK.
Wolfgang J ParakPhilipps University of Marburg, Renthof 7, 35032, Marburg, Germany.
Beatriz PelazPhilipps University of Marburg, Renthof 7, 35032, Marburg, Germany.
Shareen H DoakInstitute of Life Science, Swansea University Medical School, Singleton Park, Swansea, SA2 8PP, UK.
Uwe HimmelreichBiomedical NMR Unit/MoSAIC, KU Leuven Campus Gasthuisberg, Herestraat 49, 3000, Louvain, Belgium.
Stefaan J SoenenBiomedical NMR Unit/MoSAIC, KU Leuven Campus Gasthuisberg, Herestraat 49, 3000, Louvain, Belgium.
Ghent University · BEPhilipps University of Marburg · DESwansea University · GBKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNanoparticle interactions with cellular membranes and the kinetics of their transport and localization are important determinants of their functionality and their biological consequences. Understanding these phenomena is fundamental for the translation of such NPs from in vitro to in vivo systems for bioimaging and medical applications. Two CdSe/ZnS quantum dots (QD) with differing surface functionality (NH

resultsIn water, the COOH- and NH

conclusionsTogether, these data reveal that although cellular QD levels were similar after 24 h, differences in the nature and extent of their cellular trafficking resulted in differences in consequent gene alterations and toxicological effects.

Indexed as

AutophagyCadmium CompoundsCell LineGene Expression RegulationHumansLysosomesMitochondriaQuantum DotsReactive Oxygen SpeciesSelenium CompoundsSulfidesZinc CompoundsCadmium Compoundscadmium selenideReactive Oxygen SpeciesSelenium CompoundsSulfidesZinc Compoundszinc sulfideEndosomal uptakeGene alterationsIntracellular localizationNanotoxicityQuantum dot NPs

Identifiers

PMID28619032
PMCPMC5472855
OpenAlexW2625081716

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.