ReviewBMC psychiatry2017
Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms.
Review in BMC psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A systematic review of personality and musculoskeletal disorders: evidence from general population studies.Frontiers in psychiatry · 2024Pooled it
- Psychological trauma as a transdiagnostic risk factor for mental disorder: an umbrella meta-analysis.European archives of psychiatry and clinical neuroscience · 2023Pooled it
- Internet-based cognitive and behavioural therapies for post-traumatic stress disorder (PTSD) in adults.The Cochrane database of systematic reviews · 2021Pooled it
- Clinical Features, Neuropsychology and Neuroimaging in Bipolar and Borderline Personality Disorder: A Systematic Review of Cross-Diagnostic Studies.Frontiers in psychiatry · 2021Pooled it
- Trichotillomania and skin-picking disorder: associations with childhood maltreatment and the mediating role of depressive symptoms.BMC psychology · 2026Article
- Uncertainty of Fit - Serving People with Borderline Personality Disorder on an Assertive Community Treatment Team Setting: Experiences and Perspectives of Clinicians from a Flexible ACT Team.Community mental health journal · 2026Article
- The Experience of Participating in Individual Placement and Support (IPS) Employment Program: Perspectives of Four Individuals with Borderline Personality Disorder.Community mental health journal · 2026Article
- A theory-driven rationale for EMDR therapy among patients with a personality disorder.Frontiers in psychology · 2026Review
- Psychiatric comorbidities and sexual health risks in HIV-serodiscordant heterosexual couples involving women with borderline personality disorder: a mixed-method study and theoretical modeling.Frontiers in psychiatry · 2026Article
- Associations Between Adverse Childhood Experiences and Prenatal Depression Mediated Through Family Communication in Chinese Pregnant Women: Causal Mediation Analysis.Depression and anxiety · 2026Article
- White matter microstructural abnormalities related to emotional dysfunction and childhood trauma characterize adolescents with borderline personality disorder.Brain imaging and behavior · 2025Article
- Review
- The Psychopathological Domains of Attachment Trauma: A Proposal for a Clinical Conceptualization.Clinical neuropsychiatry · 2025Article
- Neural Correlates of Borderline Personality Disorder (BPD) Based on Electroencephalogram (EEG)-A Mechanistic Review.International journal of molecular sciences · 2025Review
- Exploring the Relationship Between Childhood Maltreatment, Alexithymia, and Facial Emotional Recognition in Schizophrenia.Brain and behavior · 2025Article
- Mechanisms of childhood trauma: an integrative review of a multimodal, transdiagnostic pathway.Neurobiology of stress · 2025Review
- Role of Early Trauma on Defense Mechanisms and Coping Strategies in Personality Disorders.Medicina (Kaunas, Lithuania) · 2025Article
- Review
- Social camouflaging predicts eating disorder symptomatology among female patients with Borderline Personality Disorder.Frontiers in psychiatry · 2025Article
- Borderline personality: revisiting its classification as a neurodevelopmental disorder.Frontiers in psychiatry · 2025Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccording to several studies, the onset of the Borderline Personality Disorder (BPD) depends on the combination between genetic and environmental factors (GxE), in particular between biological vulnerabilities and the exposure to traumatic experiences during childhood. We have searched for studies reporting possible alterations in several biological processes and brain morphological features in relation to childhood trauma experiences and to BPD. We have also looked for epigenetic mechanisms as they could be mediators of the effects of childhood trauma in BPD vulnerability. DISCUSSION: We prove the role of alterations in Hypothalamic-Pituitary-Adrenal (HPA) axis, in neurotrasmission, in the endogenous opioid system and in neuroplasticity in the childhood trauma-associated vulnerability to develop BPD; we also confirm the presence of morphological changes in several BPD brain areas and in particular in those involved in stress response. Not so many studies are available on epigenetic changes in BPD patients, although these mechanisms are widely investigated in relation to stress-related disorders. A better comprehension of the biological and epigenetic mechanisms, affected by childhood trauma and altered in BPD patients, could allow to identify "at high risk" subjects and to prevent or minimize the development of the disease later in life.
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