Evidence map›Paper›PMID 28619005›Full record

Trial reportBMC anesthesiology2017

Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial.

Vineya Rai Hakumat Rai, Lee Fern Phang, Sheau Fung Sia, Amirah Amir, Jeyaganesh S Veerakumaran, Mustafa Kassim Abdulazez Kassim, Rafidah Othman, Pei Chien Tah, Pui San Loh, Mohamad Irfan Othman Jailani and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03166449 (Effects of Immunonutrition on Biomarkers in Traumatic Brain Injury Patients in Malaysia), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03166449 nacompletednot on this map

Effects of Immunonutrition on Biomarkers in Traumatic Brain Injury Patients in Malaysia: a Prospective Randomized Controlled Trial.

TypeinterventionalSponsorUniversity of MalayaRan2014 to 2015Enrolled36ConditionsTraumatic Brain Injury, Immuno-Deficiency, Nutrient DeficiencyArmsNeomune, Fresubin® HP energy
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Review
  7. Article
  8. Nutrition in the Neurocritical Care Unit: a New Frontier.Current treatment options in neurology · 2021
    Review
  9. The Effect of Probiotics in Stroke Treatment.Evidence-based complementary and alternative medicine : eCAM · 2021
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Vineya Rai Hakumat RaiSchool of Medicine, Taylor's University, Lakeside Campus, 47500, Subang Jaya, Malaysia.
Lee Fern PhangDepartment of Anaesthesiology, Hospital Umum Sarawak, Jalan Hospital, 93586, Kuching, Sarawak, Malaysia.
Sheau Fung SiaDivision of Neurosurgery, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Amirah AmirDepartment of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. amirahamir@ummc.edu.my.ORCID 0000-0001-9189-8925
Jeyaganesh S VeerakumaranDepartment of Anaesthesiology, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia.
Mustafa Kassim Abdulazez KassimDepartment of Anaesthesiology, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia.
Rafidah OthmanDepartment of Dietetics, University Malaya Medical Centre, 50603, Kuala Lumpur, Malaysia.
Pei Chien TahDepartment of Dietetics, University Malaya Medical Centre, 50603, Kuala Lumpur, Malaysia.
Pui San LohDepartment of Anaesthesiology, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia.
Mohamad Irfan Othman JailaniDepartment of Anaesthesiology, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia.
Gracie OngDepartment of Anaesthesiology, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia.
University of Malaya · MYUniversity Malaya Medical Centre · MYHospital Kuala Lumpur · MYSarawak General Hospital · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHead injury is one of the top three diagnosis leading to intensive care unit (ICU) admission in Malaysia. There has been growing interest in using immunonutrition as a mode of modulating the inflammatory response to injury or infection with the aim of improving clinical outcome. The aim of the present study was to evaluate the effect of an immunonutrition on biomarkers (IL-6, glutathione, CRP, total protein and albumin) in traumatic brain injury patients.

methodsThirty six patients with head injury admitted to neurosurgical ICU in University Malaya Medical Centre were recruited for this study, over a 6-month period from July 2014 to January 2015. Patients were randomized to receive either an immunonutrition (Group A) or a standard (Group B) enteral feed. Levels of biomarkers were measured at day 1, 5 and 7 of enteral feeding.

resultsPatients in Group A showed significant reduction of IL-6 at day 5 (p < 0.001) with concurrent rise in glutathione levels (p = 0.049). Patients in Group A also demonstrated a significant increase of total protein level at the end of the study (day 7).

conclusionThese findings indicate the potential of immunonutrition reducing cytokines and increasing antioxidant indices in patients with TBI. However, further studies incorporating patient outcomes are needed to determine its overall clinical benefits.

trial registrationNational Medical Research Register (NMRR) ID: 14-1430-23,171. ClinicalTrials.gov identifier: NCT03166449 .

Indexed as

Enteral NutritionFood, FormulatedAdolescentAdultAgedAmino AcidsBiomarkersBlood ProteinsBrain Injuries, TraumaticC-Reactive ProteinFemaleGlutathioneHumansInterleukin-6MaleMiddle AgedAmino AcidsBiomarkersBlood ProteinsC-Reactive ProteinGlutathioneInterleukin-6Serum AlbuminBiomarkersCytokinesEnteral nutritionImmunonutritionNeomuneTraumatic brain injury

Identifiers

PMID28619005
PMCPMC5472912
OpenAlexW2625487938

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.