Evidence map›Paper›PMID 28618868›Full record

ArticleCartilage2017

Appropriate Use Criteria for Hyaluronic Acid in the Treatment of Knee Osteoarthritis in the United States.

Arup K Bhadra, Roy Altman, Vinod Dasa, Karen Myrick, Jeffrey Rosen, Vijay Vad, Peter Vitanzo, Michelle Bruno, Hillary Kleiner, Caryn Just

2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cartilage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05414617 nacompletednot on this mapstarted 2022, after this paper: background citation

Prospective, Multicenter, Open Study Evaluating the Short-term Safety of Use of Pandora Administered in the Form of 1 Intra-articular Injection of Happyone or 3 Intra-articular Injections of Happysoft in Patients Suffering From Gonarthrosis

TypeinterventionalSponsorLabrhaRan2022 to 2023Enrolled20ConditionsKnee OsteoarthritisArmsIntra-articular single injection, Intra-articular three injections
NCT05978180 nacompletednot on this mapstarted 2023, after this paper: background citation

Prospective, Multicenter, Randomized, Parallel Groups Study Comparing the Safety and the Efficacy of the Administration of One Intra-articular Injection of 4.8 ml (HO-1) or Three Intra-articular Injections of 2.2 ml (HS-3) of Pandora Gel to One Intra-articular Injection of 2.5 ml (SINOVIAL®ONE), in Symptomatic Gonarthrosis

TypeinterventionalSponsorLabrhaRan2023 to 2025Enrolled252ConditionsKnee OsteoarthritisArmsMedical Device : HO-1, Medical Device : HS-3, Medical Device : SINOVIAL® ONE
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Arup K Bhadra1 Northeast Orthopedics and Sports Medicine, Airmont, NY, USA.
Roy Altman2 Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.
Vinod Dasa3 LSU Health Sciences Center Department of Orthopaedics, New Orleans, LA, USA.
Karen Myrick5 Quinnipiac University School of Nursing, Joint Appointment Frank Netter School of Medicine, North Haven, CT, USA.
Jeffrey Rosen7 Department of Orthopaedics and Rehabilitation, New York-Presbyterian/Queens Hospital, New York, NY, USA.
Vijay Vad9 Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY, USA.
Peter Vitanzo10 Rothman Institute at Jefferson, Philadelphia, PA, USA.
Michelle Bruno11 Avalere Health, Washington, DC, USA.
Hillary Kleiner11 Avalere Health, Washington, DC, USA.
Caryn Just11 Avalere Health, Washington, DC, USA.
Prevea Health · USHospital for Special Surgery · USLouisiana State University Health Sciences Center New Orleans · USNew York Hospital Queens · USRonald Reagan UCLA Medical Center · USRothman Institute · USSt. Cloud Orthopedic Associates · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA workgroup of clinical experts has developed an Appropriate Use Criteria (AUC) for the use of hyaluronic acid (HA) in the treatment of osteoarthritis (OA) of the knee. The increasingly broad and varied use of HA injections, lack of published clinical guidance, and limited coverage for their use has created the imperative to establish appropriateness criteria.

methodsThe experts of this workgroup represent rheumatology, orthopedic surgery, physiatry, sports medicine, and nursing clinicians with substantive knowledge of intra-articular HA therapy. This workgroup utilized the results of a systematic review of evidence, expert clinical opinion, and current evidence-based clinical practice guidelines to develop appropriateness criteria for the use of intra-articular HA for knee OA in 17 real-world clinical scenarios.

resultsThe workgroup scored the appropriateness of treatment of each patient scenario using a 9-point scale to designate a treatment as appropriate (7-9), uncertain (4-6), or inappropriate (1-3). Six scenarios were scored as appropriate, 10 scenarios were scored as uncertain, and 1 scenario was scored as inappropriate.

conclusionThis article can assist clinicians in shared decision-making by providing best practices in considering HA injections for knee OA treatment. Moreover, this AUC article can aid payers and policy makers in determining reimbursement and preauthorization policies and more appropriately managing health care resources. It is clear that further research is still necessary-particularly in patient populations differentiated by OA severity-that may benefit the greatest from the use of HA injections for the treatment of knee OA.

Indexed as

appropriate use criteriahyaluronic acidkneeosteoarthritisviscosupplementation

Identifiers

PMID28618868
PMCPMC5625860
OpenAlexW2517880123

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.