ArticleThe Journal of the Acoustical Society of America2017
Low-intensity ultrasound activates vestibular otolith organs through acoustic radiation force.
Article in The Journal of the Acoustical Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Utricular Compound Action Potential Thresholds to Pulsed Interaural Vibration in Guinea Pig, and Mechanical Tuning Curve Estimates in Mouse, Rat, Sheep, and Human.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- A Comprehensive Review of Low-Intensity Focused Ultrasound Parameters and Applications in Neurologic and Psychiatric Disorders.Neuromodulation : journal of the International Neuromodulation Society · 2025Review
- Vestibular prosthesis: from basic research to clinics.Frontiers in integrative neuroscience · 2023Review
- A mathematical model for mechanical activation and compound action potential generation by the utricle in response to sound and vibration.Frontiers in neurology · 2023Article
- Use of Ultrasonic Cleaning Technology in the Whole Process of Fruit and Vegetable Processing.Foods (Basel, Switzerland) · 2022Review
- Review of Audiovestibular Symptoms Following Exposure to Acoustic and Electromagnetic Energy Outside Conventional Human Hearing.Frontiers in neurology · 2020Review
- Multiscale modeling of mechanotransduction in the utricle.Journal of neurophysiology · 2019Review
- Semicircular canal biomechanics in health and disease.Journal of neurophysiology · 2019Review
- Sound abnormally stimulates the vestibular system in canal dehiscence syndrome by generating pathological fluid-mechanical waves.Scientific reports · 2018Article
- Ultrasound Elicits Behavioral Responses through Mechanical Effects on Neurons and Ion Channels in a Simple Nervous System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Neuromodulation with transcranial focused ultrasound.Neurosurgical focus · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The present study examined the efficacy of 5 MHz low-intensity focused ultrasound (LiFU) as a stimulus to remotely activate inner ear vestibular otolith organs. The otolith organs are the primary sensory apparati responsible for detecting orientation of the head relative to gravity and linear acceleration in three-dimensional space. These organs also respond to loud sounds and vibration of the temporal bone. The oyster toadfish, Opsanus tau, was used to facilitate unobstructed acoustic access to the otolith organs in vivo. Single-unit responses to amplitude-modulated LiFU were recorded in afferent neurons identified as innervating the utricle or the saccule. Neural responses were equivalent to direct mechanical stimulation, and arose from the nonlinear acoustic radiation force acting on the otolithic mass. The magnitude of the acoustic radiation force acting on the otolith was measured ex vivo. Results demonstrate that LiFU stimuli can be tuned to mimic directional forces occurring naturally during physiological movements of the head, loud air conducted sound, or bone conducted vibration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.