ArticleCell host & microbe2017
IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance.
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Article in Cell host & microbe, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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159citing papers in PubMed, 1 pooled it
17.4field-weighted citation impact, top 1% of its field
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Who cites it
159 citing papers in PubMed, 1 synthesis or guideline pooled it, 254 citations in OpenAlex.
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- DNA From Neutrophil Extracellular Traps Restricts Group 3 Innate Lymphoid Cells Function in Intestinal Epithelial Repair via CCDC25.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
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- Possible Involvement of the Mucosal Claudin Expression in the Healing of a Refractory Ileocecal Ulcer in a Patient with Crohn's Disease Successfully Treated with Infliximab.Internal medicine (Tokyo, Japan) · 2026Article
- Resident microbes shape host immunity and protect against pathogen infection and inflammatory disease.Cellular and molecular life sciences : CMLS · 2026Review
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- Infectious Diarrhea in Early Childhood across the Global South: Etiologic Diversity and Pathogenic Mechanisms.ACS infectious diseases · 2026Review
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- Tight Junction Defects in Aganglionic and Ganglionic Colon in Children With Hirschsprung Disease.Laboratory investigation; a journal of technical methods and pathology · 2026Article
- Gut microbiota-derived metabolites and IL-22 signaling in inflammatory bowel disease: context-dependent regulation of mucosal repair and inflammation.Frontiers in immunology · 2026Review
- Unlocking New Treatment Horizons for Celiac Disease: PRKCD Revealed as a Promising Target through Mendelian RandomizationEndocrine, metabolic & immune disorders drug targets · 2026Article
- Rehydration rescues Il22Nature communications · 2025Article
- Intestinal epithelial PTPN2 limits pathobiont colonization by immune-directed antimicrobial responses.Gut microbes · 2025Article
- Butyrate-producing commensal bacteria confers colon immune defense function via enhancing H4K31 Crotonylation of macrophages.Microbiome · 2025Article
- Main genetic factors associated with inflammatory bowel diseases and their consequences on intestinal permeability: involvement in gut inflammation.Journal of gastroenterology · 2025Review
99 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Pei-Yun TsaiDepartment of Pathology, The University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA.
Bingkun ZhangState Key Laboratory of Animal Nutrition, Department of Animal Nutrition & Feed Science, College of Animal Science & Technology, China Agricultural University, Haidian District, Beijing 100193, China; Department of Pathology, The University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA.
Wei-Qi HeDepartment of Pathology, The University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA; Cambridge-Suda (CAM-SU) Genome Resource Center, Soochow University, Suzhou 215123, China.
Juan-Min ZhaDepartment of Pathology, The University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA; Cambridge-Suda (CAM-SU) Genome Resource Center, Soochow University, Suzhou 215123, China; Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Matthew A OdenwaldDepartment of Pathology, The University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA.
Gurminder SinghDepartment of Pathology, The University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA; Departments of Pathology and Medicine (Gastroenterology), Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Atsushi TamuraLaboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.
Le ShenDepartment of Pathology, The University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA.
Anne SailerDepartment of Pathology, The University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA.
Sunil YeruvaDepartment of Pathology, The University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA; Departments of Pathology and Medicine (Gastroenterology), Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Wei-Ting KuoDepartments of Pathology and Medicine (Gastroenterology), Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Yang-Xin FuDepartment of Pathology, The University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA; Department of Pathology, University of Texas Southwestern, Dallas, TX 75235, USA.
Sachiko TsukitaLaboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.
Jerrold R TurnerDepartment of Pathology, The University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA; Departments of Pathology and Medicine (Gastroenterology), Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: jrturner@bwh.harvard.edu.
University of Chicago · USBrigham and Women's Hospital · USSoochow University · CNThe University of Osaka · JP
Funding
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Scott B Snapper · 1986 to 2026
$32.4MZO-1-MEDIATED PROTEIN INTERACTIONS: REGULATORS AND INTEGRATORS OF DIVERSE EPITHELIAL FUNCTIONS IN HEALTH AND DISEASER01DK061931 · NIDDK · UNIVERSITY OF CHICAGO · PI JERROLD R. TURNER · 2001 to 2026
$15.0MRuth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)T32HD007009 · NICHD · UNIVERSITY OF CHICAGO · PI NANCY B SCHWARTZ · 1985 to 2026
$13.0MTherapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease.R01DK068271 · NIDDK · UNIVERSITY OF CHICAGO · PI JERROLD R. TURNER · 2005 to 2026
$11.3MTranslational Approaches to Develop Drug Therapy for DiarrheaR24DK099803 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2014 to 2019
$8.9MContribution of occludin to intestinal homeostasis and diseaseK01DK092381 · NIDDK · UNIVERSITY OF CHICAGO · PI SHEN, LE · 2012 to 2016
$751kAdvanced Multi-color Confocal and FRAP-SAC MicroscopeS10RR025643 · NCRR · UNIVERSITY OF CHICAGO · PI TURNER, JERROLD R. · 2010 to 2010
$500kCytoskeletal mechanisms of epithelial morphogenesisF30DK103511 · NIDDK · UNIVERSITY OF CHICAGO · PI ODENWALD, MATTHEW · 2014 to 2016
$124kTIGHT JUNCTION REGULATION IN INTESTINAL EPITHELIUMF32DK009180 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI TURNER, JERROLD R. · 1994 to 1996
–NCRR NIH HHS S10 RR025643NICHD NIH HHS T32 HD007009NIDDK NIH HHS F30 DK103511NIDDK NIH HHS F32 DK009180NIDDK NIH HHS K01 DK092381NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK061931NIDDK NIH HHS R01 DK068271NIDDK NIH HHS R24 DK099803
Abstract
Diarrhea is a host response to enteric pathogens, but its impact on pathogenesis remains poorly defined. By infecting mice with the attaching and effacing bacteria Citrobacter rodentium, we defined the mechanisms and contributions of diarrhea and intestinal barrier loss to host defense. Increased permeability occurred within 2 days of infection and coincided with IL-22-dependent upregulation of the epithelial tight junction protein claudin-2. Permeability increases were limited to small molecules, as expected for the paracellular water and Na
Indexed as
Up-RegulationAnimalsCell Membrane PermeabilityCitrobacter rodentiumClaudin-2ColitisCytokinesDiarrheaDisease Models, AnimalEnterobacteriaceae InfectionsEpitheliumImmunity, InnateInterleukin-22InterleukinsIntestinal MucosaIntestinesClaudin-2CytokinesInterleukin-22InterleukinsSodiumWaterbacterial infectioncolitisdiarrheaenteric infectioninnate defensepermeabilitytight junction
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.