Evidence map›Paper›PMID 28617989›Full record

ArticleImmunology2017

1,25-dihydroxyvitamin D

Zhongxiang Xie, Jingtao Chen, Chao Zheng, Jing Wu, Yun Cheng, Shan Zhu, Chenhong Lin, Qingqing Cao, Jie Zhu, Tao Jin

Open access · bronzeAbstract read
In one paragraph

Article in Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Talin 1 plays a significant role in the development of tolerogenic dendritic cells, which may contribute to the progression of multiple sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  10. Targeting Talin1 to reprogram dendritic cell activation landscapes: A mechanistically grounded cell therapy for multiple sclerosis model.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  11. Article
  12. Vitamin D affects antiphospholipid syndrome by regulating T cells (Review).International journal of molecular medicine · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Zhongxiang XieDepartment of Neurology and Neuroscience Centre, The First Hospital of Jilin University, Changchun, China.
Jingtao ChenInstitute of Translational Medicine, The First Hospital of Jilin University, Changchun, China.
Chao ZhengDepartment of Neurology and Neuroscience Centre, The First Hospital of Jilin University, Changchun, China.
Jing WuInstitute of Translational Medicine, The First Hospital of Jilin University, Changchun, China.
Yun ChengDepartment of Neurology and Neuroscience Centre, The First Hospital of Jilin University, Changchun, China.
Shan ZhuInstitute of Translational Medicine, The First Hospital of Jilin University, Changchun, China.
Chenhong LinDepartment of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
Qingqing CaoDepartment of Neurology and Neuroscience Centre, The First Hospital of Jilin University, Changchun, China.
Jie ZhuDepartment of Neurology and Neuroscience Centre, The First Hospital of Jilin University, Changchun, China.
Tao JinDepartment of Neurology and Neuroscience Centre, The First Hospital of Jilin University, Changchun, China.ORCID 0000-0002-7028-3419
Jilin University · CNKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs), a bridge for innate and adaptive immune responses, play a key role in the development of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model for MS. Administration of tolerogenic DCs has been used as an immunotherapy in autoimmune diseases. Deficiency of vitamin D is an environmental risk factor of MS. In this study, we induced tolerogenic DCs by 1,25-dihydroxyvitamin D

Indexed as

Adoptive TransferAnimalsB-Lymphocytes, RegulatoryCells, CulturedChemotaxis, LeukocyteDendritic CellsEncephalomyelitis, Autoimmune, ExperimentalErgocalciferolsFemaleImmune ToleranceImmunoglobulin GImmunologic FactorsInterleukin-10Lymph NodesMice, Inbred C57BLSpinal Cord1,25-dihydroxyergocalciferolErgocalciferolsIL10 protein, mouseImmunoglobulin GImmunologic FactorsInterleukin-10Tumor Necrosis Factor-alpha1,25-dihydroxyvitamin D3experimental autoimmune encephalomyelitismultiple sclerosistolerogenic dendritic cells

Identifiers

PMID28617989
PMCPMC5629429
OpenAlexW2626469179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.