Evidence map›Paper›PMID 28617942›Full record

ArticleClinical and experimental immunology2017

Withasteroid B from D. metel L. regulates immune responses by modulating the JAK/STAT pathway and the IL-17

Y Su, Q Wang, B Yang, L Wu, G Cheng, H Kuang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Identification ofVaccines · 2020
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Y SuKey Laboratory of Chinese Material Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin, China.ORCID 0000-0002-4955-9986
Q WangSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
B YangKey Laboratory of Chinese Material Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin, China.
L WuKey Laboratory of Chinese Material Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin, China.
G ChengDepartment of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA.
H KuangKey Laboratory of Chinese Material Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin, China.
Heilongjiang University of Chinese Medicine · CNUniversity of California, Los Angeles · USGuangdong Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Datura metel L. is a medicinal herb that contains withasteroids and has a wide range of biological activities. We isolated seven withasteroids from the flowers of D. metel L and examined their ability to inhibit immune responses in vitro and in vivo. Among the withasteroids, withasteroid B2 exhibited the strongest inhibitory effect on immune responses comparing B2 with other isolated compounds from D. metel L., including suppressing the differentiation of CD4

Indexed as

AnimalsCell DifferentiationCells, CulturedDatura metelDisease Models, AnimalForkhead Transcription FactorsHumansImmunomodulationImmunosuppressive AgentsInterleukin-10Interleukin-17Interleukin-23Janus KinasesMiceMice, Inbred BALB CMice, Inbred C57BLForkhead Transcription FactorsFoxp3 protein, mouseImmunosuppressive AgentsInterleukin-10Interleukin-17Interleukin-23Janus KinasesNuclear Receptor Subfamily 1, Group F, Member 3STAT Transcription FactorsWithanolideswithasteroid Bautoimmune diseaseIL-17+RORγt+/IL-10+FoxP3+ ratioJAK/STAT pathways

Identifiers

PMID28617942
PMCPMC5588778
OpenAlexW2625201673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.