ArticleJournal of biomedical optics2017
Automated circumferential construction of first-order aqueous humor outflow pathways using spectral-domain optical coherence tomography.
Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Circumferential multi-contrast mapping of the aqueous outflow pathway in human eyes facilitated by circular-scan optical coherence tomography angiography.Biomedical optics express · 2026Article
- Robotic Optical Coherence Tomography With Expanded Three-Dimensional Field-of-View Using Point-Cloud-Based Volumetric Montaging.IEEE transactions on medical imaging · 2025Article
- Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response.Investigative ophthalmology & visual science · 2025Article
- Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response.bioRxiv : the preprint server for biology · 2024Article
- Reduced Aqueous Humor Outflow Pathway Arborization in Childhood Glaucoma Eyes.Translational vision science & technology · 2024Article
- Imaging fine structures of the human trabecular meshworkBiomedical optics express · 2023Article
- Iridocorneal angle imaging of a human donor eye by spectral-domain optical coherence tomography.Scientific reports · 2023Article
- Evaluation of Schlemm's canal with swept-source optical coherence tomography in primary angle-closure disease.BMC ophthalmology · 2023Article
- Article
- Characterization of the human iridocorneal angleBiomedical optics express · 2022Article
- Subconjunctival Lymphatics Respond to VEGFC and Anti-Metabolites in Rabbit and Mouse Eyes.Investigative ophthalmology & visual science · 2022Article
- The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques.Frontiers in medicine · 2022Review
- Open-source deep learning-based automatic segmentation of mouse Schlemm's canal in optical coherence tomography images.Experimental eye research · 2022Article
- Structural Confirmation of Lymphatic Outflow from Subconjunctival Blebs of Live Human Subjects.Ophthalmology science · 2021Article
- Full circumferential morphological analysis of Schlemm's canal in human eyes using megahertz swept source OCT.Biomedical optics express · 2021Article
- Functional, structural, and molecular identification of lymphatic outflow from subconjunctival blebs.Experimental eye research · 2020Article
- Segmental differences found in aqueous angiographic-determined high - and low-flow regions of human trabecular meshwork.Experimental eye research · 2020Article
- Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT.PloS one · 2020Observational
- Cellular and cytoskeletal alterations of scleral fibroblasts in response to glucocorticoid steroids.Experimental eye research · 2019Article
- Fluorescein Aqueous Angiography in Live Normal Human Eyes.Journal of glaucoma · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The purpose was to create a three-dimensional (3-D) model of circumferential aqueous humor outflow (AHO) in a living human eye with an automated detection algorithm for Schlemm’s canal (SC) and first-order collector channels (CC) applied to spectral-domain optical coherence tomography (SD-OCT). Anterior segment SD-OCT scans from a subject were acquired circumferentially around the limbus. A Bayesian Ridge method was used to approximate the location of the SC on infrared confocal laser scanning ophthalmoscopic images with a cross multiplication tool developed to initiate SC/CC detection automated through a fuzzy hidden Markov Chain approach. Automatic segmentation of SC and initial CC’s was manually confirmed by two masked graders. Outflow pathways detected by the segmentation algorithm were reconstructed into a 3-D representation of AHO. Overall, only <1% of images (5114 total B-scans) were ungradable. Automatic segmentation algorithm performed well with SC detection 98.3% of the time and <0.1% false positive detection compared to expert grader consensus. CC was detected 84.2% of the time with 1.4% false positive detection. 3-D representation of AHO pathways demonstrated variably thicker and thinner SC with some clear CC roots. Circumferential (360 deg), automated, and validated AHO detection of angle structures in the living human eye with reconstruction was possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.