ArticleInflammatory bowel diseases2017
Longitudinal Patterns of Medication Nonadherence and Associated Health Care Costs.
Article in Inflammatory bowel diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Management of paediatric ulcerative colitis, part 1: Ambulatory care-An updated evidence-based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation.Journal of pediatric gastroenterology and nutrition · 2025Guideline
- Patient-Reported Outcomes for Pediatric Adherence and Self-Management: A Systematic Review.Journal of pediatric psychology · 2020Pooled it
- A data-driven typology of asthma medication adherence using cluster analysis.Scientific reports · 2020Trial
- Longitudinal non-adherence predicts treatment escalation in paediatric ulcerative colitis.Alimentary pharmacology & therapeutics · 2019Trial
- Article
- Medication nonadherence - definition, measurement, prevalence, and causes: reflecting on the past 20 years and looking forwards.Frontiers in pharmacology · 2025Review
- A biobehavioural and social-structural model of inflammation and executive function in pediatric chronic health conditions.Health psychology review · 2024Article
- Choosing Therapy for Moderate to Severe Crohn's Disease.Journal of the Canadian Association of Gastroenterology · 2024Article
- Self-Management assistance for recommended treatment (SMART) IBD app randomized control trial in adolescents with IBD: Design and methodology.Health care transitions · 2024Article
- Trajectories of adherence to intravenous biological treatment in patients with inflammatory bowel disease: a longitudinal analysis.Frontiers in pharmacology · 2024Article
- Digital Therapeutic Self-Management Intervention in Adolescents With Inflammatory Bowel Disease.Journal of pediatric gastroenterology and nutrition · 2023Article
- A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and Persistence With Inflammatory Bowel Disease Therapy (ASSIST Study): Protocol for a Randomized Controlled Trial.JMIR research protocols · 2022Article
- Racial Disparities in Medication Adherence Barriers: Pediatric Epilepsy as an Exemplar.Journal of pediatric psychology · 2022Observational
- Predicting medication nonadherence risk in the Chinese type 2 diabetes mellitus population - establishment of a new risk nomogram model: a retrospective study.The Journal of international medical research · 2021Article
- The Development and Proof of Principle Test of TRIAGE: A Practical Question Set to Identify and Discuss Medication-Related Problems in Community Pharmacy.Pharmacy (Basel, Switzerland) · 2020Article
- Article
- A Micro-longitudinal Approach to Measuring Medication Adherence in Pediatric Inflammatory Bowel Diseases.Journal of pediatric gastroenterology and nutrition · 2020Article
- Risk Factors for Medication Nonadherence to Self-Injectable Biologic Therapy in Adult Patients With Inflammatory Bowel Disease.Inflammatory bowel diseases · 2020Article
- Trajectories of adherence to mood stabilizers in patients with bipolar disorder.International journal of bipolar disorders · 2019Article
- Advancing the Science and Practice of Medication Adherence.Journal of general internal medicine · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundNonadherence to treatment recommendations is associated with poorer outcomes in inflammatory bowel disease and may increase the cost of care. We examined the longitudinal relationship between nonadherence and health care costs and hypothesized that at least 3 distinct trajectories of nonadherence would be observed and that increasing nonadherence would account for significantly greater health care costs after controlling for disease activity.
methodsNinety-nine patients aged 2 to 21 years with inflammatory bowel disease were recruited into this 2-year longitudinal study. Medication possession ratios were calculated from pharmacy refill data, disease activity ratings were obtained from medical charts, and hospital and physician charges associated with an International Classification of Diseases, Ninth Revision code for ulcerative colitis or Crohn's disease were obtained from the hospital's accounting database.
resultsAn average total cost effect size of d = 0.68 was observed between the increasing severity and stable low severity groups, but the confidence intervals overlap. Conversely, patients with increasing nonadherence demonstrated significantly higher health care costs than patients with stable ≤10%, stable 11% to 20%, or decreasing nonadherence.
conclusionsMedication nonadherence is related to increased health care costs after controlling for disease severity. Patients with increasing nonadherence over time demonstrate more than a 3-fold increase in costs compared with adherent patients. In addition, patients whose adherence improves over time incur approximately the same costs as those who are consistently adherent. This suggests that, in addition to leveraging prevention efforts to keep patients from becoming more nonadherent as treatment continues, efforts aimed at modifying adherence behavior may result in significant cost savings over time.
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