Evidence map›Paper›PMID 28617321›Full record

ArticleInternational journal of molecular sciences2017

Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI.

Stephanie Trend, Anderson P Jones, Sian Geldenhuys, Scott N Byrne, Marzena J Fabis-Pedrini, David Nolan, David R Booth, William M Carroll, Robyn M Lucas, Allan G Kermode and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  6. Advances in Multiple Sclerosis 2017.International journal of molecular sciences · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Stephanie TrendTelethon Kids Institute, University of Western Australia, Perth, WA 6008, Australia. stephanie.trend@telethonkids.org.au.
Anderson P JonesTelethon Kids Institute, University of Western Australia, Perth, WA 6008, Australia. anderson.jones@telethonkids.org.au.
Sian GeldenhuysTelethon Kids Institute, University of Western Australia, Perth, WA 6008, Australia. sian.geldenhuys@telethonkids.org.au.
Scott N ByrneCellular Photoimmunology Group, Infectious Diseases & Immunology, Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia. scott.byrne@sydney.edu.au.
Marzena J Fabis-PedriniCentre for Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science, University of Western Australia, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia. marzena.pedrini@perron.uwa.edu.au.
David NolanImmunology Department, Royal Perth Hospital, Perth, WA 6000, Australia. d.nolan@iiid.murdoch.edu.au.
David R BoothCentre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Sydney, NSW 2006, Australia. david.booth@sydney.edu.au.
William M CarrollCentre for Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science, University of Western Australia, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia. robyn.lucas@anu.edu.au.
Robyn M LucasNational Centre for Epidemiology & Population Health, Research School of Population Health, Australian National University, Canberra, ACT 0200, Australia. robyn.lucas@anu.edu.au.
Allan G KermodeCentre for Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science, University of Western Australia, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia. kermode@me.com.
Prue H HartTelethon Kids Institute, University of Western Australia, Perth, WA 6008, Australia. prue.hart@telethonkids.org.au.
The Kids Research Institute Australia · AUMurdoch University · AUThe University of Sydney · AUThe University of Western Australia · AUAustralian National University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is not clear how the profile of immune cells in peripheral blood differs between patients with clinically isolated syndrome (CIS) and healthy controls (HC). This study aimed to identify a CIS peripheral blood signature that may provide clues for potential immunomodulatory approaches early in disease. Peripheral blood mononuclear cells (PBMCs) were collected from 18 people with CIS, 19 HC and 13 individuals with other demyelinating conditions (ODC) including multiple sclerosis (MS). Individuals with CIS separated into two groups, namely those with early (≤14 days post-diagnostic magnetic resonance imaging (MRI);

Indexed as

AdolescentAdultAgedBlood CellsB-LymphocytesDemyelinating DiseasesDisease ProgressionFemaleHumansKiller Cells, NaturalLeukocytes, MononuclearMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisYoung AdultB cellsclinically isolated syndromeimmunologymultiple sclerosisNK cellspathology

Identifiers

PMID28617321
PMCPMC5486099
OpenAlexW2626788197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.