ArticleeLife2017
A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Status of research on the application of melatonin in insomnia based on bibliometric visualization analysis and development trends.Frontiers in psychiatry · 2025Pooled it
- SEX-DEPENDENT MODULATION OF WHOLE BRAIN cFOS EXPRESSION BY LIGHT AND MELANOPSIN IN THE MOUSE.bioRxiv : the preprint server for biology · 2026Article
- Melanopsin regulates axonal translation underlying retinohypothalamic circuit assembly.bioRxiv : the preprint server for biology · 2026Article
- Light tunes long-term threat avoidance behavior in male mice.Nature communications · 2026Article
- Prolonged Light Exposure Induces Long-Lasting Retinal Wave Plasticity via Retrograde Melanopsin-Dopamine Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Amplifying and ameliorating light avoidance in mice with photoreceptor targeting and calcitonin gene-related peptide sensitization.Headache · 2026Article
- Genetic tuning of retinal ganglion cell subtype identity to drive visual behavior.Nature communications · 2025Article
- Discrete photoentrainment of mammalian central clock is regulated by bi-stable dynamic network in the suprachiasmatic nucleus.Nature communications · 2025Article
- Light-eye-body axis: exploring the network from retinal illumination to systemic regulation.Theranostics · 2025Review
- Light modulates glucose and lipid homeostasis via the sympathetic nervous system.Science advances · 2024Article
- Retinal ganglion cell circuits and glial interactions in humans and mice.Trends in neurosciences · 2024Review
- Developmental control of rod number via a light-dependent retrograde pathway from intrinsically photosensitive retinal ganglion cells.Developmental cell · 2024Article
- Light modulates glucose and lipid homeostasis via the sympathetic nervous system.bioRxiv : the preprint server for biology · 2024Article
- Defining spatial nonuniformities of all ipRGC types using an improved Opn4Cell reports methods · 2024Article
- Flp-recombinase mouse line for genetic manipulation of ipRGCs.bioRxiv : the preprint server for biology · 2024Article
- A newbioRxiv : the preprint server for biology · 2024Article
- Light affects the prefrontal cortex via intrinsically photosensitive retinal ganglion cells.Science advances · 2024Article
- A Comprehensive Overview of the Neural Mechanisms of Light Therapy.Neuroscience bulletin · 2024Review
- Contribution of the eye and of opn4xa function to circadian photoentrainment in the diurnal zebrafish.PLoS genetics · 2024Article
- Preservation of Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) in Late Adult Mice: Implications as a Potential Biomarker for Early Onset Ocular Degenerative Diseases.Investigative ophthalmology & visual science · 2024Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
The visual system consists of two major subsystems, image-forming circuits that drive conscious vision and non-image-forming circuits for behaviors such as circadian photoentrainment. While historically considered non-overlapping, recent evidence has uncovered crosstalk between these subsystems. Here, we investigated shared developmental mechanisms. We revealed an unprecedented role for light in the maturation of the circadian clock and discovered that intrinsically photosensitive retinal ganglion cells (ipRGCs) are critical for this refinement process. In addition, ipRGCs regulate retinal waves independent of light, and developmental ablation of a subset of ipRGCs disrupts eye-specific segregation of retinogeniculate projections. Specifically, a subset of ipRGCs, comprising ~200 cells and which project intraretinally and to circadian centers in the brain, are sufficient to mediate both of these developmental processes. Thus, this subset of ipRGCs constitute a shared node in the neural networks that mediate light-dependent maturation of the circadian clock and light-independent refinement of retinogeniculate projections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.