Evidence map›Paper›PMID 28617224›Full record

ArticleBMC bioinformatics2017

ENIGMA-Viewer: interactive visualization strategies for conveying effect sizes in meta-analysis.

Guohao Zhang, Peter Kochunov, Elliot Hong, Sinead Kelly, Christopher Whelan, Neda Jahanshad, Paul Thompson, Jian Chen

Open access · goldAbstract read
In one paragraph

Article in BMC bioinformatics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Guohao ZhangDepartment of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, 21250, MD, USA.
Peter KochunovMaryland Psychiatric Research Center, University of Maryland, Baltimore, 55 Wade Ave, Baltimore, 21228, MD, USA. pkochunov@mprc.umaryland.edu.
Elliot HongMaryland Psychiatric Research Center, University of Maryland, Baltimore, 55 Wade Ave, Baltimore, 21228, MD, USA.
Sinead KellyDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, 02215, MA, USA.
Christopher WhelanImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, 1975 Zonal Ave, Los Angeles, 90033, LA, USA.
Neda JahanshadKeck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, 90033, LA, USA.
Paul ThompsonKeck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, 90033, LA, USA.
Jian ChenDepartment of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, 21250, MD, USA. jichen@umbc.edu.
University of Southern California · USUniversity of Maryland, Baltimore · USUniversity of Maryland, Baltimore County · USBeth Israel Deaconess Medical Center · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2012 to 2022
$14.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
Amish Connectome Project on Mental IllnessU01MH108148 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT, KOCHUNOV, PETER V. · 2015 to 2018
$4.3M
Neurodevelopment and Imaging among HIV-infected Children from the PREDICT studyR01MH089722 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VALCOUR, VICTOR · 2010 to 2014
$3.1M
Searching for Endophenotypes of Bipolar DisorderR01MH085667 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SOARES, JAIR C · 2012 to 2016
$3.0M
HARDI Mapping of Disease Effects on the BrainR01EB008432 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2009 to 2012
$2.6M
Alzheimer's disease risk analyzed using population imaging genomicsR01AG040060 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2011 to 2016
$2.5M
Genetic Influences on Human Neuroanatomical ShapesR01MH094343 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2012 to 2016
$2.4M
Predicting Brain Changes in HIV/AIDSR01NS080655 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NAVIA, BRADFORD, THOMPSON, PAUL M · 2012 to 2015
$2.3M
Empowering Personalized Medicine: Integrating Imaging, Genetics, and BiomarkersR01MH097268 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COPPOLA, GIOVANNI, THOMPSON, PAUL M · 2012 to 2014
$1.3M
NIA NIH HHS R01 AG040060NIA NIH HHS U01 AG024904NIBIB NIH HHS P41 EB015922NIBIB NIH HHS R01 EB008432NIBIB NIH HHS R01 EB015611NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH085667NIMH NIH HHS R01 MH089722NIMH NIH HHS R01 MH094343NIMH NIH HHS R01 MH097268NIMH NIH HHS R01 MH112180NIMH NIH HHS U01 MH108148NINDS NIH HHS R01 NS080655
6 · The paper itself

Abstract

backgroundGlobal scale brain research collaborations such as the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) consortium are beginning to collect data in large quantity and to conduct meta-analyses using uniformed protocols. It becomes strategically important that the results can be communicated among brain scientists effectively. Traditional graphs and charts failed to convey the complex shapes of brain structures which are essential to the understanding of the result statistics from the analyses. These problems could be addressed using interactive visualization strategies that can link those statistics with brain structures in order to provide a better interface to understand brain research results.

resultsWe present ENIGMA-Viewer, an interactive web-based visualization tool for brain scientists to compare statistics such as effect sizes from meta-analysis results on standardized ROIs (regions-of-interest) across multiple studies. The tool incorporates visualization design principles such as focus+context and visual data fusion to enable users to better understand the statistics on brain structures. To demonstrate the usability of the tool, three examples using recent research data are discussed via case studies.

conclusionsENIGMA-Viewer supports presentations and communications of brain research results through effective visualization designs. By linking visualizations of both statistics and structures, users can gain more insights into the presented data that are otherwise difficult to obtain. ENIGMA-Viewer is an open-source tool, the source code and sample data are publicly accessible through the NITRC website ( http://www.nitrc.org/projects/enigmaviewer_20 ). The tool can also be directly accessed online ( http://enigma-viewer.org ).

Indexed as

Meta-Analysis as TopicSoftwareBrainComputational BiologyHumansImage Processing, Computer-AssistedNeuroimagingComparative studiesDiffusion tensor imagingEffect sizeInteractive visualizationMeta-analysis

Identifiers

PMID28617224
PMCPMC5471941
OpenAlexW2623919980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.