ArticleJournal of medicinal chemistry2017
Synthesis and Preclinical Characterization of a Cationic Iodinated Imaging Contrast Agent (CA4+) and Its Use for Quantitative Computed Tomography of Ex Vivo Human Hip Cartilage.
Article in Journal of medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Assessment of morphology, radiopacity gradient and mechanical properties of articular cartilage with contrast-enhanced high-resolution peripheral quantitative computed tomography.Frontiers in bioengineering and biotechnology · 2026Article
- Development of 5-Amino-2,4,6-triiodoisophthalic Acid Derivatives for Carbamoylation of Amino Acids.ChemistryOpen · 2025Article
- Assessment of CA4+ Impact on Mechanical Properties of Articular Cartilage.Materials (Basel, Switzerland) · 2025Article
- Photon-counting in dual-contrast-enhanced computed tomography: a proof-of-concept quantitative biomechanical assessment of articular cartilage.Scientific reports · 2024Article
- Non-enzymatic glycation reduces glucose transport in the human cartilage endplate independently of matrix porosity or proteoglycan content.JOR spine · 2024Article
- Global research hotspots and trends of iodinated contrast agents in medical imaging: a bibliometric and visualization analysis.Frontiers in medicine · 2024Article
- Article
- Evaluation of a lanthanide nanoparticle-based contrast agent for microcomputed tomography of porous channels in subchondral bone.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Revealing the three-dimensional murine brain microstructure by contrast-enhanced computed tomography.Frontiers in neuroscience · 2023Article
- Cryogenic contrast-enhanced microCT enables nondestructive 3D quantitative histopathology of soft biological tissues.Nature communications · 2022Article
- A Cationic Contrast Agent in X-ray Imaging of Articular Cartilage: Pre-Clinical Evaluation of Diffusion and Attenuation Properties.Diagnostics (Basel, Switzerland) · 2022Article
- Cationic Contrast Agents for Computed Tomography of Cartilage for Early Diagnosis of Osteoarthritis.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Effects of human articular cartilage constituents on simultaneous diffusion of cationic and nonionic contrast agents.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Quantitative Evaluation of Equine Articular Cartilage Using Cationic Contrast-Enhanced Computed Tomography.Cartilage · 2021Article
- Comparative Tribology: Articulation-induced rehydration of cartilage across species.Biotribology (Oxford) · 2021Article
- Influence of fixation on CA4+ contrast enhanced microCT of articular cartilage and subsequent feasibility for histological evaluation.American journal of translational research · 2021Article
- Biofabrication of a shape-stable auricular structure for the reconstruction of ear deformities.Materials today. Bio · 2021Article
- dGEMRIC and CECT Comparison of Cationic and Anionic Contrast Agents in Cadaveric Human Metacarpal Cartilage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Synchrotron MicroCT Reveals the Potential of the Dual Contrast Technique for Quantitative Assessment of Human Articular Cartilage Composition.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Triple Contrast CT Method Enables Simultaneous Evaluation of Articular Cartilage Composition and Segmentation.Annals of biomedical engineering · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Contrast agents that go beyond qualitative visualization and enable quantitative assessments of functional tissue performance represent the next generation of clinically useful imaging tools. An optimized and efficient large-scale synthesis of a cationic iodinated contrast agent (CA4+) is described for imaging articular cartilage. Contrast-enhanced CT (CECT) using CA4+ reveals significantly greater agent uptake of CA4+ in articular cartilage compared to that of similar anionic or nonionic agents, and CA4+ uptake follows Donnan equilibrium theory. The CA4+ CECT attenuation obtained from imaging ex vivo human hip cartilage correlates with the glycosaminoglycan content, equilibrium modulus, and coefficient of friction, which are key indicators of cartilage functional performance and osteoarthritis stage. Finally, preliminary toxicity studies in a rat model show no adverse events, and a pharmacokinetics study documents a peak plasma concentration 30 min after dosing, with the agent no longer present in vivo at 96 h via excretion in the urine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.