Evidence map›Paper›PMID 28616946›Full record

ArticleBiomaterials science2017

Glycocalyx scaffolding with synthetic nanoscale glycomaterials.

Mia L Huang, Sean C Purcell, Stephen Verespy, Yinan Wang, Kamil Godula

Abstract read
In one paragraph

Article in Biomaterials science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Compressed Cells Facilitate Adhesion Through Glycocalyx.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Glycocalyx Scaffolding to Control Cell Surface Glycan Displays.Current protocols in chemical biology · 2018
    Article
  10. A caged metabolic precursor for DT-diaphorase-responsive cell labeling.Chemical communications (Cambridge, England) · 2018
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mia L HuangDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, MC 0358, La Jolla, CA, USA. kgodula@ucsd.edu.
Sean C PurcellDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, MC 0358, La Jolla, CA, USA. kgodula@ucsd.edu.
Stephen VerespyDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, MC 0358, La Jolla, CA, USA. kgodula@ucsd.edu.
Yinan WangDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, MC 0358, La Jolla, CA, USA. kgodula@ucsd.edu.
Kamil GodulaDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, MC 0358, La Jolla, CA, USA. kgodula@ucsd.edu.ORCID 0000-0001-7953-4619

Funding

Siglec Modulation of Inflammatory ResponsesP01HL107150 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LE, DZUNG T · 2011 to 2017
$18.0M
In vivo glycan engineering at the cell-matrix interface to control stem cell fateDP2HD087954 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GODULA, KAMIL · 2015 to 2015
$2.3M
Chemical editing of nanoscale proteoglycan architecture and organization to control cellularR00HD090292 · NICHD · SCRIPPS FLORIDA · PI HUANG, MIA L · 2018 to 2020
$900k
Glycan array for phenotype-driven capture and genotyping of viruses in primary isolatesR21AI129894 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAGNEUX, PASCAL, GODULA, KAMIL · 2016 to 2017
$601k
Chemical editing of nanoscale proteoglycan architecture and organization to control cellular differentiationK99HD090292 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HUANG, MIA L · 2017 to 2017
$130k
NHLBI NIH HHS P01 HL107150NIAID NIH HHS R21 AI129894NICHD NIH HHS DP2 HD087954NICHD NIH HHS K99 HD090292NICHD NIH HHS R00 HD090292
6 · The paper itself

Abstract

We report a method for programming complexity into the glycocalyx of live cells. Via a combination of glycomaterial synthesis and membrane remodeling, we have engineered cells to display native-like, mixed sialoglycan populations, while confining the activity of each glycan into a specific nanoscale presentation.

Indexed as

AnimalsChemistry Techniques, SyntheticCHO CellsCricetinaeCricetulusGlycocalyxNanostructuresPolysaccharidesPolysaccharides

Identifiers

PMID28616946
PMCPMC5560263

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.