Evidence map›Paper›PMID 28616874›Full record

Trial reportBritish journal of haematology2017

Romiplostim monotherapy in thrombocytopenic patients with myelodysplastic syndromes: long-term safety and efficacy.

Pierre Fenaux, Petra Muus, Hagop Kantarjian, Roger M Lyons, Richard A Larson, Mikkael A Sekeres, Pamela S Becker, Amelia Orejudos, Janet Franklin

Abstract readClinical TrialMulticenter Study
In one paragraph

Trial report in British journal of haematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
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  15. Myelodysplastic syndromes.Nature reviews. Disease primers · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pierre FenauxService d'Hématologie Clinique, Hôpital St. Louis and Paris 7 University, Paris, France.ORCID 0000-0002-0468-3553
Petra MuusDepartment of Haematology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Hagop KantarjianDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Roger M LyonsTexas Oncology and US Oncology Research, San Antonio, TX, USA.
Richard A LarsonUniversity of Chicago Comprehensive Cancer Center, Chicago, IL, USA.
Mikkael A SekeresCleveland Clinic, Taussig Cancer Center, Cleveland, OH, USA.
Pamela S BeckerUniversity of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Amelia OrejudosAmgen Inc., Morganville, NJ, USA.
Janet FranklinAmgen Inc., Thousand Oaks, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Romiplostim can improve platelet counts in about 50% of patients with low- or intermediate 1-risk (lower risk) myelodysplastic syndromes (MDS) and thrombocytopenia, but its long-term toxicity and efficacy are not known. This open-label extension study evaluated the long-term safety and efficacy of romiplostim in 60 patients with lower risk MDS and platelet counts ≤50 × 10

Indexed as

AdultAgedAged, 80 and overDisease ProgressionDrug Administration ScheduleFemaleFollow-Up StudiesHematologic AgentsHemorrhageHumansLeukemia, Myeloid, AcuteMaleMiddle AgedMyelodysplastic SyndromesPlatelet CountReceptors, FcHematologic AgentsMPL protein, humanReceptors, FcReceptors, ThrombopoietinRecombinant Fusion ProteinsromiplostimThrombopoietinmyelodysplastic syndromesplateletsromiplostimthrombocytopeniathrombopoietin receptor agonist

Identifiers

PMID28616874
PMCPMC5600084

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.