Evidence map›Paper›PMID 28616842›Full record

ArticleMolecular imaging and biology2018

Characterization of Magneto-Endosymbionts as MRI Cell Labeling and Tracking Agents.

Kimberly D Brewer, Ryan Spitler, Kayla R Lee, Andrea C Chan, Joyce C Barrozo, Abdul Wakeel, Chandler S Foote, Steven Machtaler, James Rioux, Juergen K Willmann and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Multinuclear MRI in Drug Discovery.Molecules (Basel, Switzerland) · 2022
    Review
  2. Article
  3. Article
  4. Article
  5. Stem Cell Tracing Through MR Molecular Imaging.Tissue engineering and regenerative medicine · 2018
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Kimberly D BrewerBiomedical Translational Imaging Centre (BIOTIC), Halifax, Nova Scotia, Canada.
Ryan SpitlerRadiology Department and Molecular Imaging Program (MIPS), Stanford University, Stanford, CA, USA.
Kayla R LeeBell Biosystems, San Francisco, CA, USA.
Andrea C ChanBell Biosystems, San Francisco, CA, USA.
Joyce C BarrozoBell Biosystems, San Francisco, CA, USA.
Abdul WakeelBell Biosystems, San Francisco, CA, USA.
Chandler S FooteBell Biosystems, San Francisco, CA, USA.
Steven MachtalerRadiology Department and Molecular Imaging Program (MIPS), Stanford University, Stanford, CA, USA.
James RiouxBiomedical Translational Imaging Centre (BIOTIC), Halifax, Nova Scotia, Canada.
Juergen K WillmannRadiology Department and Molecular Imaging Program (MIPS), Stanford University, Stanford, CA, USA.
Papia ChakrabortyBell Biosystems, San Francisco, CA, USA.
Bradley W RiceBell Biosystems, San Francisco, CA, USA.
Christopher H ContagRadiology Department and Molecular Imaging Program (MIPS), Stanford University, Stanford, CA, USA.
Caleb B BellBell Biosystems, San Francisco, CA, USA.
Brian K RuttRadiology Department and Molecular Imaging Program (MIPS), Stanford University, Stanford, CA, USA. brutt@stanford.edu.
Bell Biosystems (United States) · USStanford University · USPrecision BioLogic (Canada) · CALucas Research · US

Funding

STANFORD CANCER IMAGING TRAINING (SCIT) PROGRAMT32CA009695 · NCI · STANFORD UNIVERSITY · PI BRUCE L DANIEL, Jeremy Dahl · 1993 to 2026
$7.7M
Next Generation 7T MRI Platform Upgrade with Parallel Transmit CapabilitiesS10RR026351 · NCRR · STANFORD UNIVERSITY · PI RUTT, BRIAN KEITH · 2011 to 2011
$600k
Single Cell Spatiotemporal and Functional Reporting using Magneto-EndosymbiontsR43TR001202 · NCATS · BELL BIOSYSTEMS, INC. · PI BELL, CALEB B., RUTT, BRIAN KEITH · 2015 to 2015
$225k
California Institute for Regenerative Medicine RT2-02018NCATS NIH HHS R43 TR001202NCI NIH HHS T32 CA 009695NCI NIH HHS T32 CA009695NCRR NIH HHS S10 RR026351NIH HHS 1R43TR001202-01
6 · The paper itself

Abstract

purposeMagneto-endosymbionts (MEs) show promise as living magnetic resonance imaging (MRI) contrast agents for in vivo cell tracking. Here we characterize the biomedical imaging properties of ME contrast agents, in vitro and in vivo. PROCEDURES: By adapting and engineering magnetotactic bacteria to the intracellular niche, we are creating magneto-endosymbionts (MEs) that offer advantages relative to passive iron-based contrast agents (superparamagnetic iron oxides, SPIOs) for cell tracking. This work presents a biomedical imaging characterization of MEs including: MRI transverse relaxivity (r

resultsAt 7T, r

conclusionsOur results demonstrate the potential of magneto-endosymbionts as living MR contrast agents. They have r

Indexed as

Cell TrackingMagnetic Resonance ImagingSymbiosisAnimalsCell Line, TumorCell SurvivalFemaleHumansMagnetite NanoparticlesMice, NudeMagnetite NanoparticlesCell trackingIronLabeled cellsMagnetic resonance imaging (MRI)MagnetiteMagnetotactic bacteria

Identifiers

PMID28616842
PMCPMC5730509
OpenAlexW2712562384

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.