ArticleAnnals of intensive care2017
Assessment of renal hemodynamic toxicity of fluid challenge with 0.9% NaCl compared to balanced crystalloid (PlasmaLyte
Article in Annals of intensive care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Why physiology will continue to guide the choice between balanced crystalloids and normal saline: a systematic review and meta-analysis.Critical care (London, England) · 2019Pooled it
- Effects of Plasma-Lyte.½ and 0.9% saline in renal function after deceased-donor kidney transplant: a randomized controlled trial.Brazilian journal of anesthesiology (Elsevier)Trial
- Pathophysiology and management of crush syndrome: A narrative review.World journal of orthopedics · 2025Article
- Protective effect of omega-3 polyunsaturated fatty acids on sepsis via the AMPK/mTOR pathway.Pharmaceutical biology · 2023Article
- Electrolyte imbalance in infectious disease patients at King Abdulaziz Hospital, Jeddah.Journal of Taibah University Medical Sciences · 2022Article
- Hospital-Acquired Serum Chloride Derangements and Associated In-Hospital Mortality.Medicines (Basel, Switzerland) · 2020Article
- Hyperchloremia is not associated with AKI or death in septic shock patients: results of a post hoc analysis of the "HYPER2S" trial.Annals of intensive care · 2019Article
- "I don't get no respect": the role of chloride in acute kidney injury.American journal of physiology. Renal physiology · 2019Review
- Beneficial effects of antioxidant therapy in crush syndrome in a rodent model: enough evidences to be used in humans?Annals of intensive care · 2018Article
- Serum chloride levels in critical illness-the hidden story.Intensive care medicine experimental · 2018Review
- Retrospective Evaluation of the Prognosis and Prevalence of Hyperchloremia in Dogs and Cats.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccording to international guidelines, volume expansion with crystalloids is the first-line treatment for hemodynamic management in patients with severe sepsis or septic shock. Compared to balanced crystalloids, 0.9% sodium chloride (0.9% NaCl) induces hyperchloremia and metabolic acidosis and may alter renal hemodynamics and function. We compared the effects of 0.9% NaCl to a less chloride-concentrated fluid, PlasmaLyte
resultsA sepsis with hypotension was induced by cecal ligature and puncture (CLP) in 40 male Wistar rats (20 for each crystalloid). Rats received fluid resuscitation over a period of 200 min for a targeted mean arterial pressure of 90 mm Hg. Animals received similar volumes of 0.9% NaCl or PL. Unlike PL-resuscitated rats, 0.9% NaCl-resuscitated rats experienced hyperchloremia and metabolic acidosis, whereas systemic hemodynamics, renal hemodynamics and renal function were not significantly different between both groups.
conclusionIn our model of rats with severe sepsis resuscitated with large amounts of crystalloids, 0.9% NaCl-induced hyperchloremic acidosis, but balanced crystalloid did not improve systemic and renal hemodynamics or renal function.
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