Evidence map›Paper›PMID 28616825›Full record

ArticleJournal of endocrinological investigation2017

Correlation of cardio-metabolic parameters with vitamin D status in healthy premenopausal women.

S Giovinazzo, A Alibrandi, A Campennì, F Trimarchi, R M Ruggeri

Abstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Observational
  5. Vitamin D status and cardiovascular outcome.Journal of endocrinological investigation · 2019
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

S GiovinazzoDepartment of Clinical and Experimental Medicine, Unit of Endocrinology, University of Messina, AOU Policlinico "G. Martino" (Pad H, 4th Floor), Via Consolare Valeria, 1, 98125, Messina, Italy. salvogiovi@yahoo.it.
A AlibrandiDepartment of Economics, Unit of Statistical and Mathematical Sciences, University of Messina, Messina, Italy.
A CampennìDepartment of Biomedical Sciences and Morpho-Functional Imaging, University of Messina, Messina, Italy.
F TrimarchiAccademia Peloritana dei Pericolanti, University of Messina, Messina, Italy.
R M RuggeriDepartment of Clinical and Experimental Medicine, Unit of Endocrinology, University of Messina, AOU Policlinico "G. Martino" (Pad H, 4th Floor), Via Consolare Valeria, 1, 98125, Messina, Italy.
University of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeVitamin D has been associated with metabolic disorders and increasing risk of cardiovascular diseases, with conflicting results. Aim of our study was to evaluate the relationship, if any, between cardio-metabolic risk factors and serum 25(OH)D concentrations in healthy women in premenopausal age.

methodsWe enrolled 200 healthy women, aged 19-50 years (mean age ± SD, 38 ± 11 years). In each subject, we measured serum 25(OH)D in relation to metabolic biomarkers and cardiovascular parameters.

resultsA status of vitamin D deficiency was found in 48% of the study population, while 38% showed levels higher than 30 ng/ml. Fasting glucose and insulin levels were significantly higher in subjects with vitamin D deficiency/insufficiency (P = 0.034 and P = 0.049, respectively) as well as HOMA-IR (P = 0.05). HDL cholesterol was significantly lower (P = 0.024) and intima-media thickness (IMT) higher (P = 0.014) in the vitamin D deficient/insufficient subjects. Moreover, serum 25(OH)D levels inversely correlated with insulin levels (P = 0.0001) and intima-media thickness (P = 0.015), and directly with serum HDL cholesterol (P = 0.010). At univariate regression analysis, the parameters that were significantly associated with vitamin D levels were insulin (P = 0.050), HDL cholesterol (P = 0.016), and intima-media thickness (P = 0.015). At multivariate analysis adjusted for age and BMI, vitamin D was still significantly associated with HDL cholesterol and intima-media thickness.

conclusionsA positive association between vitamin D and HDL cholesterol was found in healthy women without any evidence of metabolic disorders, with a significant inverse correlation between vitamin D and IMT. These results suggest a possible protective role of 25(OH)D in cardiovascular disorders.

Indexed as

Carotid Intima-Media ThicknessAdultBiomarkersBlood GlucoseCardiovascular DiseasesCholesterol, HDLFemaleFollow-Up StudiesHumansInsulinMetabolic SyndromeMiddle AgedPremenopausePrognosisRisk FactorsVitamin DBiomarkersBlood GlucoseCholesterol, HDLInsulinVitamin DVitaminsCardiovascular riskHigh-density lipoprotein (HDL) cholesterolHypovitaminosis DIntima–media thicknessVitamin D

Identifiers

PMID28616825
OpenAlexW2744009917

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.