ArticleEuropean radiology2017
Preliminary study of diffusion kurtosis imaging in thyroid nodules and its histopathologic correlation.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of Diffusion-Weighted Magnetic Resonance Imaging Parameters on Diagnostic Accuracy for Thyroid Nodules: A Systematic Review and Meta-Analysis.Journal of magnetic resonance imaging : JMRI · 2026Pooled it
- Review
- A multifunctional MRI model based on IVIM and DKI predicts HIF-1α, Ki-67, and VEGF status in breast carcinoma.Frontiers in oncology · 2025Article
- DKI andBMC medical imaging · 2024Article
- Prediction model based on MRI morphological features for distinguishing benign and malignant thyroid nodules.BMC cancer · 2024Article
- Unenhanced magnetic resonance imaging of papillary thyroid carcinoma with emphasis on diffusion kurtosis imaging.Quantitative imaging in medicine and surgery · 2023Article
- Quantitative differentiation of malignant and benign thyroid nodules with multi-parameter diffusion-weighted imaging.World journal of clinical cases · 2022Article
- Dual-source dual-energy computed tomography-derived quantitative parameters combined with machine learning for the differential diagnosis of benign and malignant thyroid nodules.Quantitative imaging in medicine and surgery · 2022Article
- Comparison of the Differential Diagnostic Performance of Intravoxel Incoherent Motion Imaging and Diffusion Kurtosis Imaging in Malignant and Benign Thyroid Nodules.Frontiers in oncology · 2022Article
- A Noninvasive Assessment of Tumor Proliferation in Lung cancer Patients using Intravoxel Incoherent Motion Magnetic Resonance Imaging.Journal of Cancer · 2021Article
- Radiomics Nomogram for Identifying Sub-1 cm Benign and Malignant Thyroid Lesions.Frontiers in oncology · 2021Article
- Intravoxel incoherent motion and ADC measurements for differentiating benign from malignant thyroid nodules: utilizing the most repeatable region of interest delineation at 3.0 T.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020Article
- Quantitative analyses of the correlation between dynamic contrast-enhanced MRI and intravoxel incoherent motion DWI in thyroid nodules.American journal of translational research · 2020Article
- Magnetic Resonance Imaging for Translational Research in Oncology.Journal of clinical medicine · 2019Review
- Association Between VEGF Expression and Diffusion Weighted Imaging in Several Tumors-A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2019Article
- Diffusion kurtosis imaging provides quantitative assessment of the microstructure changes of disc degeneration: an in vivo experimental study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019Article
- Whole-lesion ADC histogram analysis is not able to reflect microvessel density in HNSCC.Medicine · 2019Article
- Development and validation of an ultrasound-based nomogram to improve the diagnostic accuracy for malignant thyroid nodules.European radiology · 2019Article
- Efficacy of apparent diffusion coefficient in predicting aggressive histological features of papillary thyroid carcinoma.Diagnostic and interventional radiology (Ankara, Turkey) · 2018Article
- Preclinical Imaging for the Study of Mouse Models of Thyroid Cancer.International journal of molecular sciences · 2017Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesTo evaluate the utility of diffusion kurtosis imaging (DKI) of patients with thyroid nodules and to assess the probable correlation with histopathological factors.
methodsThe study included 58 consecutive patients with thyroid nodules who underwent magnetic resonance imaging (MRI) examination, including DKI and diffusion-weighted imaging (DWI). Histopathological analysis of paraffin sections included cell density and immunohistochemical analysis of Ki-67 and vascular endothelial growth factor (VEGF). Statistical analyses were performed using Student's t-test, receiver operating characteristic (ROC) curves and Spearman's correlation.
resultsThe diffusion parameters, cell density and immunohistochemistry analysis between malignant and benign lesions showed significant differences. The largest area under the ROC curve was acquired for the D value (AUC = 0.797). The highest sensitivity was shown with the use of K (threshold = 0.832, sensitivity = 0.917). The Ki-67 expression generally stayed low. A moderate correlation was found between ADC, D and cell density (r = -0.536, P = 0.000; r = -0.570, P = 0.000) and ADC, D and VEGF expression (r = -0.451, P = 0.000; r = -0.522, P = 0.000).
conclusionThe DKI-derived parameters D and K demonstrated an advantage compared to conventional DWI for thyroid lesion diagnosis. While the histopathological study indicated that the D value correlated better with extracellular change than the ADC value, the K value probably changed relative to the intracellular structure. KEY POINTS: • DWI and DKI parameters can identify PTC from benign thyroid nodules. • Correlations were found between diffusion parameters and histopathological analysis. • DKI obtains better diagnostic accuracy than conventional DWI.
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