ArticleInternational orthopaedics2017
Preparation of a biphase composite scaffold and its application in tissue engineering for femoral osteochondral defects in rabbits.
Article in International orthopaedics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- 3D bioprinted scaffolds for osteochondral regeneration: advancements and applications.Materials today. Bio · 2025Review
- Osteochondral tissue engineering‑based subchondral bone plate repair (Review).Molecular medicine reports · 2025Review
- Fabrication of 3-Dimensional-Printed Bilayered Scaffold Carboxymethyl Chitosan/Oxidized Xanthan Gum, Biphasic Calcium Phosphate for Osteochondral Regeneration.Biomaterials research · 2025Article
- Protecting the regenerative environment: selecting the optimal delivery vehicle for cartilage repair-a narrative review.Frontiers in bioengineering and biotechnology · 2024Review
- Multiphasic scaffolds for the repair of osteochondral defects: Outcomes of preclinical studies.Bioactive materials · 2023Review
- Three-Dimensional Silk Fibroin/Chitosan Based Microscaffold for Anticancer Drug Screening.Frontiers in bioengineering and biotechnology · 2022Article
- Angiogenic Potential of VEGF Mimetic Peptides for the Biofunctionalization of Collagen/Hydroxyapatite Composites.Biomolecules · 2021Article
- Osteochondral tissue engineering: Perspectives for clinical application and preclinical development.Journal of orthopaedic translation · 2021Review
- Long-Term Evaluation of Allogenic Chondrocyte-Loaded PVA-PCL IPN Scaffolds for Articular Cartilage Repair in Rabbits.Indian journal of orthopaedics · 2021Article
- Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing.Pharmaceutics · 2021Review
- Establishment of Collagen: Hydroxyapatite/BMP-2 Mimetic Peptide Composites.Materials (Basel, Switzerland) · 2020Article
- Biphasic Double-Network Hydrogel With Compartmentalized Loading of Bioactive Glass for Osteochondral Defect Repair.Frontiers in bioengineering and biotechnology · 2020Article
- Animal Models of Osteochondral Defect for Testing Biomaterials.Biochemistry research international · 2020Review
- [Research progress on osteochondral tissue engineering].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019Review
- Biomimetic porous silk fibroin/biphasic calcium phosphate scaffold for bone tissue regeneration.Journal of materials science. Materials in medicine · 2018Article
- [Preparation andZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018Article
- Synergistic Effects of Controlled-Released BMP-2 and VEGF from nHAC/PLGAs Scaffold on Osteogenesis.BioMed research international · 2018Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThree-dimensional bioactive scaffolds are useful tools for stem cell implant in tissue-engineering. For chondral and subchondral repair, the chondroinductive and osteoinductive property of a scaffold is a major challenge. The scaffolds that aim to osteogenic differentiation have been well studied. However, cartilage cells can hardly be induced for osteogenesis, and monophase scaffolds cannot ideally repair both cartilage and subchondral defects at the same time.
methodsWe developed a novel biphase composite scaffold and observe its application osteochondral defects. We combined the advantages of silk-fibroin/chitosan (SF/CS) scaffold in chondrogenic differentiation and the silk-fibroin/chitosan/nano-hydroxyapatite (SF/CS/nHA) scaffold in osteogenic differentiation and bone regeneration, and synthesized a SF/CS-SF/CS/nHA scaffold, which contained both the chondrocytic phase (SF/CS) and the osteoblastic phase (SF/CS/nHA).
resultsThe biphase scaffold exhibited a porosity ratio around 90% and a water absorption ratio about 822%. A similar degradation property to traditional monophase scaffolds was observed. Bone mesenchymal stem cells (BMSCs) showed a good proliferation on this scaffold. Expression of two types of collagen was inducable for BMSCs on the scaffold. Neoformative extracellular matrix integrated with the scaffold was observed by the scanning electron microscope. When implanted in the lesion site in the rabbit femur with cartilage injury, mixing and filling function were exerted by the cell-scaffold constructs (CSCs). Micro-CT scanning revealed both chondral and subchondral layers were repaired. Moreover, type I and II collagens were both expressed in the implanted CSCs.
conclusionsChondral and subchondral repair can be achieved using the biphase scaffold implant that permits both chondrogenesis and osteogenesis from BMSCs. This approach has the potential to be clinically used for tissue engineering implantation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.