Evidence map›Paper›PMID 28616448›Full record

ArticleEuropean journal of radiology open2017

Adaptive statistical iterative reconstruction improves image quality without affecting perfusion CT quantitation in primary colorectal cancer.

D Prezzi, V Goh, S Virdi, S Mallett, C Grierson, D J Breen, PROSPeCT Investigators

Open access · goldAbstract read
In one paragraph

Article in European journal of radiology open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

D PrezziDivision of Imaging Sciences & Biomedical Engineering, King's College London, 4th Floor, Lambeth Wing, St. Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, United Kingdom.
V GohDivision of Imaging Sciences & Biomedical Engineering, King's College London, 4th Floor, Lambeth Wing, St. Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, United Kingdom.
S VirdiDivision of Imaging Sciences & Biomedical Engineering, King's College London, 4th Floor, Lambeth Wing, St. Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, United Kingdom.
S MallettInstitute of Applied Health Research, University of Birmingham, United Kingdom.
C GriersonUniversity Hospital Southampton NHS Foundation Trust, United Kingdom.
D J BreenUniversity Hospital Southampton NHS Foundation Trust, United Kingdom.
PROSPeCT Investigators
King's College London · GBUniversity Hospital Southampton NHS Foundation Trust · GBSt Thomas' Hospital · GBUniversity of Birmingham · GB

Funding

Cancer Research UK 16463Department of Health 09/22/49
6 · The paper itself

Abstract

objectivesTo determine the effect of Adaptive Statistical Iterative Reconstruction (ASIR) on perfusion CT (pCT) parameter quantitation and image quality in primary colorectal cancer.

methodsProspective observational study. Following institutional review board approval and informed consent, 32 patients with colorectal adenocarcinoma underwent pCT (100 kV, 150 mA, 120 s acquisition, axial mode). Tumour regional blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface area product (PS) were determined using identical regions-of-interests for ASIR percentages of 0%, 20%, 40%, 60%, 80% and 100%. Image noise, contrast-to-noise ratio (CNR) and pCT parameters were assessed across ASIR percentages. Coefficients of variation (CV), repeated measures analysis of variance (rANOVA) and Spearman' rank order correlation were performed with statistical significance at 5%.

resultsWith increasing ASIR percentages, image noise decreased by 33% while CNR increased by 61%; peak tumour CNR was greater than 1.5 with 60% ASIR and above. Mean BF, BV, MTT and PS differed by less than 1.8%, 2.9%, 2.5% and 2.6% across ASIR percentages. CV were 4.9%, 4.2%, 3.3% and 7.9%; rANOVA

conclusionsASIR improves image noise and CNR without altering pCT parameters substantially.

Indexed as

Colorectal neoplasmsComputer-assisted image processingMultidetector computed tomographyPerfusion imagingRadiation dosage

Identifiers

PMID28616448
PMCPMC5458094
OpenAlexW2621351514

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.