ArticleJournal of research in pharmacy practice
Severity of Gastrointestinal Side Effects of Metformin Tablet Compared to Metformin Capsule in Type 2 Diabetes Mellitus Patients.
Article in Journal of research in pharmacy practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06611501 (Glycemic Regulation as Endometriosis Adjunct Treatment), which is not on this map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Glycemic Regulation as Endometriosis Adjunct Treatment
Who cites it
29 citing papers in PubMed, 69 citations in OpenAlex.
- The Molecular Mechanisms of Metformin's Action on Blood Lipid Profile in Diabetic Patients.International journal of molecular sciences · 2026Review
- Encapsulated Indigenous Lactic Acid Bacteria Strains From Traditional Iranian Cheese Alleviate Hyperglycemia and Inflammation in Streptozotocin-Induced Diabetic Rats.Food science & nutrition · 2025Article
- Natural Products in the Clinical Management of Metabolic Syndrome.Handbook of experimental pharmacology · 2025Review
- Review
- Sodium Alginate-Starch Capsules for Enhanced Stability of Metformin in Simulated Gastrointestinal Fluids.Biomimetics (Basel, Switzerland) · 2024Article
- Article
- Prevalence of Gastroparesis and the Impact of Metformin in Diabetic Patients: A Cross-Sectional Study in Riyadh, Saudi Arabia.Gastroenterology research and practice · 2024Article
- The potential protective effect of aqueous extract ofJournal of diabetes and metabolic disorders · 2023Article
- Metformin Cessation and Dementia Incidence.JAMA network open · 2023Article
- Metallothionein-Kidney Bean Polyphenol Complexes Showed Antidiabetic Activity in Type 2 Diabetic Rats by Improving Insulin Resistance and Regulating Gut Microbiota.Foods (Basel, Switzerland) · 2023Article
- Drug target, class level, and PathFX pathway information share utility for machine learning prediction of common drug-induced side effects.Frontiers in drug safety and regulation · 2023Article
- Huangshan Maofeng Green Tea Extracts Prevent Obesity-Associated Metabolic Disorders by Maintaining Homeostasis of Gut Microbiota and Hepatic Lipid Classes in Leptin Receptor Knockout Rats.Foods (Basel, Switzerland) · 2022Article
- Metformin reverse minocycline to inhibit minocycline-resistant Acinetobacter baumannii by destroy the outer membrane and enhance membrane potential in vitro.BMC microbiology · 2022Article
- From Diabetes to Atherosclerosis: Potential of Metformin for Management of Cardiovascular Disease.International journal of molecular sciences · 2022Review
- A Qualitative Exploration of Self-Management Behaviors and Influencing Factors in Patients With Type 2 Diabetes.Frontiers in endocrinology · 2022Article
- Curcuminoids for Metabolic Syndrome: Meta-Analysis Evidences Toward Personalized Prevention and Treatment Management.Frontiers in nutrition · 2022Review
- A comparison of the effects of cinnamon, ginger, and metformin consumption on metabolic health, anthropometric indices, and sexual hormone levels in women with poly cystic ovary syndrome: A randomized double-blinded placebo-controlled clinical trial.Frontiers in nutrition · 2022Article
- Ghatti gum-base graft copolymer: a plausible platform for pH-controlled delivery of antidiabetic drugs.RSC advances · 2021Article
- Conventional and Alternative Mesenchymal Stem Cell Therapies for the Treatment of Diabetes.Advances in experimental medicine and biology · 2021Review
- Metformin as a Potential Adjuvant Antimicrobial Agent Against Multidrug Resistant Bacteria.Clinical pharmacology : advances and applications · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was designed to compare the severity of gastrointestinal (GI) side effects in Type 2 diabetes mellitus (DM) patients receiving tablet or capsule forms of metformin.
methodsIn this prospective interventional study, patients were evaluated from June to November 2016 at DM clinics affiliated to Isfahan University of Medical Sciences, Isfahan, Iran. Adult patients with Type 2 DM who were eligible for inclusion criteria switched from metformin tablet to metformin capsule. Hemoglobin A1c (HbA1c), GI side effects, and patient satisfaction based on visual analog scale (VAS) were assessed during a 6-week follow-up of receiving metformin capsule.
findingsOne hundred and three patients were evaluated, and 75 patients participated in this study. At the baseline, 40 patients (53.3%) had GI side effects due to metformin tablet which was reduced to 16 patients (21.3%) after switching to metformin capsule (
conclusionSwitching to metformin capsule may result in less GI side effects, with no further side effect complications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.