Evidence map›Paper›PMID 28616286›Full record

ArticleJournal of thoracic disease2017

Severe and uncontrolled asthma in China: a cross-sectional survey from the Australasian Severe Asthma Network.

Gang Wang, Fang Wang, Peter G Gibson, Michael Guo, Wei-Jie Zhang, Peng Gao, Hong-Ping Zhang, Erin S Harvey, Hui Li, Jie Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Corticosteroid plus βRespiratory research · 2017
    Pooled it
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Patient-centred outcomes in severe asthma: fatigue, sleep, physical activity and work.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  9. Article
  10. Effects of Family-Supported Healthcare on Children with Asthma.Therapeutics and clinical risk management · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Severe eosinophilic asthma in Chinese C-BIOPRED asthma cohort.Clinical and translational medicine · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Gang WangPneumology Group, Department of Integrated Traditional Chinese and Western Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Centre for Biotherapy, Chengdu 610041, China.
Fang WangNorman Bethune College of Medicine, Jilin University, Changchun 130021, China.
Peter G GibsonDepartment of Respiratory and Sleep Medicine, John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, Priority Research Centre for Healthy Lungs, New Lambton Heights, NSW, Australia.
Michael GuoAustralasian Severe Asthma Network, Clinical Management, Woolcock Institute of Medical Research, University of Sydney, Glebe, NSW, Australia.
Wei-Jie ZhangDepartment of Respiratory and Critical Care Medicine, The People's Hospital of Jilin Province, Changchun, Jilin 130000, China.
Peng GaoDepartment of Respiratory and Critical Care Medicine, The 2nd Affiliated Hospital, Jilin University, Changchun, Jilin 130041, China.
Hong-Ping ZhangPneumology Group, Department of Integrated Traditional Chinese and Western Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Centre for Biotherapy, Chengdu 610041, China.
Erin S HarveyAustralasian Severe Asthma Network, School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Hui LiDepartment of Respiratory and Critical Care Medicine, The People's Hospital of Jilin Province, Changchun, Jilin 130000, China.
Jie ZhangDepartment of Respiratory and Critical Care Medicine, The 2nd Affiliated Hospital, Jilin University, Changchun, Jilin 130041, China.
Hunter Medical Research Institute · AUJilin University · CNPeople 's Hospital of Jilin Province · CNFirst Bethune Hospital of Jilin University · CNSichuan University · CNState Key Laboratory of BiotherapyWoolcock Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere asthma is largely unexplored in the Chinese population. Patients with asthma underwent systematic evaluation, by investigating the characteristics of uncontrolled asthma and of asthma treated with three different controller therapies.

methodsThis multi-centre, real-world study was conducted from March 2014 to September 2015. Adults with stable asthma underwent assessment of medication use, asthma control, quality of life, psychological symptoms, work productivity and activity impairment, bronchodilator response and sputum induction.

resultsParticipants (n=379) had a mean (SD) age of 47.4 (14.0) years, and 57.0% were female. There were 14.8% (n=56) of patients receiving treatment with Step 4/5 as severe asthma, but only 13 (3.4%) met ERS/ATS severe refractory asthma criteria. The patients with severe asthma usually used triple controller therapy: ICS/LABA, additional leukotriene modifier or theophylline, and reported better asthma control. Two fifths of patients (n=147) had uncontrolled asthma, with worse symptoms, psychological symptoms (both P<0.001), health-related work productivity and activity impairment, increased eosinophilic inflammation in sputum [1.68% (0.0, 17.1%)

conclusionsAlthough there is a relatively low proportion of severe refractory asthma based on ERS/ATS criteria, two of five patients with asthma in China are uncontrolled, displaying more psychological symptoms and reduced work productivity. Substantial gain in asthma control is obtained by triple controller therapy and this may be a promising therapeutic option for persistent asthma.

Indexed as

controller therapySevere asthmauncontrolled asthma

Identifiers

PMID28616286
PMCPMC5465130
OpenAlexW2614917354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.