ArticleRegeneration (Oxford, England)2017
Planarian regeneration in space: Persistent anatomical, behavioral, and bacteriological changes induced by space travel.
Article in Regeneration (Oxford, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Spontaneous ectopic head formation enables reversal of the body axis polarity in microscopic flatworms.Proceedings. Biological sciences · 2025Article
- Evolutionary dynamics of whole-body regeneration across planarian flatworms.Nature ecology & evolution · 2023Article
- Bioprinting in Microgravity.ACS biomaterials science & engineering · 2023Review
- Artificially altered gravity elicits cell homeostasis imbalance in planarian worms, and cerium oxide nanoparticles counteract this effect.Journal of biomedical materials research. Part A · 2021Article
- Extreme Environmental Stress-Induced Biological Responses in the Planarian.BioMed research international · 2020Review
- Molecular impact of launch related dynamic vibrations and static hypergravity in planarians.NPJ microgravity · 2020Article
- Insights into the histology of planarian flatworm Phagocata gracilis based on location specific, intact lipid information provided by GCIB-ToF-SIMS imaging.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019Article
- Live imaging of intracellular pH in planarians using the ratiometric fluorescent dye SNARF-5F-AM.Biology methods & protocols · 2019Article
- The Bacterial Metabolite Indole Inhibits Regeneration of the Planarian Flatworm Dugesia japonica.iScience · 2018Article
- Bipolarity in planarians is not induced by space travel.Regeneration (Oxford, England) · 2017Article
- Space travel has effects on planarian regeneration that cannot be explained by a null hypothesis.Regeneration (Oxford, England) · 2017Article
- Planarian regeneration in space: Persistent anatomical, behavioral, and bacteriological changes induced by space travel.Regeneration (Oxford, England) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regeneration is regulated not only by chemical signals but also by physical processes, such as bioelectric gradients. How these may change in the absence of the normal gravitational and geomagnetic fields is largely unknown. Planarian flatworms were moved to the International Space Station for 5 weeks, immediately after removing their heads and tails. A control group in spring water remained on Earth. No manipulation of the planaria occurred while they were in orbit, and space-exposed worms were returned to our laboratory for analysis. One animal out of 15 regenerated into a double-headed phenotype-normally an extremely rare event. Remarkably, amputating this double-headed worm again, in plain water, resulted again in the double-headed phenotype. Moreover, even when tested 20 months after return to Earth, the space-exposed worms displayed significant quantitative differences in behavior and microbiome composition. These observations may have implications for human and animal space travelers, but could also elucidate how microgravity and hypomagnetic environments could be used to trigger desired morphological, neurological, physiological, and bacteriomic changes for various regenerative and bioengineering applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.