ArticleClinical kidney journal2017
High-dose hydroxocobalamin for vasoplegic syndrome causing false blood leak alarm.
Article in Clinical kidney journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 30 citations in OpenAlex.
- Hydroxocobalamin for the treatment of vasoplegia after lung transplantation: A case series.JHLT open · 2025Article
- Hydroxocobalamin as Rescue Therapy in a Patient With Refractory Amlodipine-Induced Vasoplegia.Cureus · 2023Article
- Vasoplegic syndrome in patients undergoing heart transplantation.Frontiers in surgery · 2023Article
- Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation.Kidney international reports · 2021Article
- The use of hydroxocobalamin for vasoplegic syndrome in left ventricular assist device patients.Clinical case reports · 2020Article
- Vasoplegia after cardiopulmonary bypass: A narrative review of pathophysiology and emerging targeted therapies.SAGE open medicine · 2020Review
- A Case of Hydroxocobalamin-Induced False Blood Leak Alarm on Dialysis Machine.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood leak alarms are important safety features in a hemodialysis machine to protect patients from loss of blood through a rupture in the dialyzer membrane (true alarms). A false blood leak alarm can be triggered by air bubbles or detector malfunction (such as deposits of grease or scale). Hydroxocobalamin is an injectable form of vitamin B12 approved by the US Food and Drug Administration for the treatment of confirmed or suspected cyanide toxicity. Due to observations of an increase in arterial pressure after high-dose hydroxocobalamin infusion for the treatment of acute cyanide poisoning, it has recently been reported as an off-label rescue treatment for post-cardiopulmonary bypass vasoplegic syndrome. We report an 83-year-old man who received hydroxocobalamin following cardiac surgery for treatment of vasoplegic syndrome. The patient developed severe acute kidney injury with volume overload. Hydroxocobalamin interference with the blood leak detector compromised his dialysis treatment. We describe the use of continuous renal replacement therapy to overcome the hydroxocobalamin-related interference with hemodialysis. As the utility of hydroxocobalamin potentially expands, physicians must be aware of its inadvertent effect on renal replacement therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.