Evidence map›Paper›PMID 28616142›Full record

ArticleChemical science2017

Alkene hydrogenation activity of enoate reductases for an environmentally benign biosynthesis of adipic acid.

Jeong Chan Joo, Anna N Khusnutdinova, Robert Flick, Taeho Kim, Uwe T Bornscheuer, Alexander F Yakunin, Radhakrishnan Mahadevan

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 97 citations in OpenAlex.

  1. Native HNature chemistry · 2026
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  16. Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases.Angewandte Chemie (International ed. in English) · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Jeong Chan JooCenter for Bio-based Chemistry , Division of Convergence Chemistry , Korea Research Institute of Chemical Technology , 141 Gajeong-ro, Yuseong-gu , Daejeon 34114 , Republic of Korea . Email: jcjoo@krict.re.kr.ORCID 0000-0001-5393-7057
Anna N KhusnutdinovaDepartment of Chemical Engineering and Applied Chemistry , University of Toronto , 200 College Street , ON M5S 3E5 , Canada . Email: a.iakounine@utoronto.ca ; Email: krishna.mahadevan@utoronto.ca.
Robert FlickDepartment of Chemical Engineering and Applied Chemistry , University of Toronto , 200 College Street , ON M5S 3E5 , Canada . Email: a.iakounine@utoronto.ca ; Email: krishna.mahadevan@utoronto.ca.
Taeho KimDepartment of Chemical Engineering and Applied Chemistry , University of Toronto , 200 College Street , ON M5S 3E5 , Canada . Email: a.iakounine@utoronto.ca ; Email: krishna.mahadevan@utoronto.ca.
Uwe T BornscheuerInstitute of Biochemistry , Department of Biotechnology & Enzyme Catalysis , Greifswald University , Felix-Hausdorff-Strasse 4 , 17487 Greifswald , Germany.
Alexander F YakuninDepartment of Chemical Engineering and Applied Chemistry , University of Toronto , 200 College Street , ON M5S 3E5 , Canada . Email: a.iakounine@utoronto.ca ; Email: krishna.mahadevan@utoronto.ca.
Radhakrishnan MahadevanDepartment of Chemical Engineering and Applied Chemistry , University of Toronto , 200 College Street , ON M5S 3E5 , Canada . Email: a.iakounine@utoronto.ca ; Email: krishna.mahadevan@utoronto.ca.
University of Toronto · CADaejeon University · KRUniversitätsmedizin Greifswald · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipic acid, a precursor for Nylon-6,6 polymer, is one of the most important commodity chemicals, which is currently produced from petroleum. The biosynthesis of adipic acid from glucose still remains challenging due to the absence of biocatalysts required for the hydrogenation of unsaturated six-carbon dicarboxylic acids to adipic acid. Here, we demonstrate the first enzymatic hydrogenation of 2-hexenedioic acid and muconic acid to adipic acid using enoate reductases (ERs). ERs can hydrogenate 2-hexenedioic acid and muconic acid producing adipic acid with a high conversion rate and yield

Identifiers

PMID28616142
PMCPMC5460604
OpenAlexW2530177418

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.