ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2017
An investigation on non-invasive fungal sinusitis; Molecular identification of etiologic agents.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- A Rare Dual Pathology in Refractory Chronic Rhinosinusitis: Maxillary Ectopic Tooth With Fungal Ball.Case reports in otolaryngology · 2026Article
- Acremonium strictum Sphenoid Sinusitis in an Immunocompetent Patient.The American journal of case reports · 2025Article
- Review
- Evaluation of metagenomic next-generation sequencing (mNGS) combined with quantitative PCR: cutting-edge methods for rapid diagnosis of non-invasive fungal rhinosinusitis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- [Analysis of curative effect of orbital apex syndrome caused by sinus disease].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
- Evaluating a semi-nested PCR to support histopathology reports of fungal rhinosinusitis in formalin-fixed paraffin-embedded tissue samples.Journal of clinical laboratory analysis · 2022Article
- Horse: a potential source of Cryptococcus neoformans and Cryptococcus gattii in Egypt.BMC veterinary research · 2022Article
- STAT6 Blockade AbrogatesFrontiers in immunology · 2022Article
- Use of Azelastine and Sodium Chloride Spray for Prevention of Sinusitis in ICU Admitted Patients: A Randomized Clinical Trial.International journal of preventive medicine · 2021Article
- Variation of virulence of five Aspergillus fumigatus isolates in four different infection models.PloS one · 2021Article
- The sino-nasal warzone: transcriptomic and genomic studies on sino-nasal aspergillosis in dogs.NPJ biofilms and microbiomes · 2020Article
- [Objective assessment of nasal function changes after revision endoscopic sinus surgery in patients with recurrent sinusitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Article
- Geotrichosis Presenting As Funguria and Asymptomatic Urinary Tract Infection in a Patient with Renal Cyst.Cureus · 2020Article
- Development of a lateral flow recombinase polymerase amplification assay for rapid and visual detection of Cryptococcus neoformans/C. gattii in cerebral spinal fluid.BMC infectious diseases · 2019Article
- Isolation and molecular characterization ofCurrent medical mycology · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFungal sinusitis is increasing worldwide in the past two decades. It is divided into two types including invasive and noninvasive. Noninvasive types contain allergic fungal sinusitis (AFS) and fungus ball. AFS is a hypersensitivity reaction to fungal allergens in the mucosa of the sinonasal tract in atopic individuals. The fungus ball is a different type of noninvasive fungal rhinosinusitis which is delineated as an accumulation of debris and fungal elements inside a paranasal sinus. Fungal sinusitis caused by various fungi such as MATERIALS AND
methodsDuring 2015-2016, a total of 100 suspected patients were examined for fungal sinusitis. Functional endoscopic sinus surgery was performed using the Messerklinger technique. Clinical samples were identified by phenotypic and molecular methods. Polymerase chain reaction (PCR) sequencing of ITS1-5.8S-ITS2 region and PCR-restriction fragment length polymorphism with
resultsTwenty-seven out of 100 suspected cases (27%) had fungal sinusitis. Nasal congestion (59%) and headache (19%) were the most common clinical signs among patients. Fifteen patients (55.5%) were male and 12 patients (44.5%) were female.
conclusionSince clinical manifestations, computed tomography scan, endoscopy, and histopathological findings are very nonspecific in AFS and fungus ball; therefore, molecular investigations are compulsory for precise identification of etiologic agents and appropriate management of these fungal infections.
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