ArticleIndian journal of psychological medicine
Adverse Drug Reactions and their Impact on Quality of Life in Patients on Antipsychotic Therapy at a Tertiary Care Center in Delhi.
Article in Indian journal of psychological medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Adverse Drug Reaction-Related Hospital Admissions and Adverse Drug Events and Their Association with Short- and Long-Term Health Outcomes in Older Adults.Geriatrics (Basel, Switzerland) · 2026Article
- Prescribing Patterns and Adverse Reactions of Antipsychotics in a North Indian Psychiatry Outpatient Department.Cureus · 2025Article
- Safety Profile of Antipsychotics as Predictors of the Quality of Life in Patients with Schizophrenia-An Inpatient Welfare Institution-Based Cross-Sectional Study.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Exploring the association of adverse drug reactions with medication adherence and quality of life among hypertensive patients: a cross-sectional study.International journal of clinical pharmacy · 2025Article
- Exploring the factors influencing the health-related quality of life in patients experiencing adverse drug reactions: a cross-sectional study.Journal of patient-reported outcomes · 2024Article
- Article
- Post marketing surveillance of suspected adverse drug reactions through spontaneous reporting: current status, challenges and the future.Therapeutic advances in drug safety · 2020Review
- Adverse drug reactions experienced by out-patients taking chlorpromazine or haloperidol at Zomba Mental Hospital, Malawi.BMC research notes · 2019Observational
- Pharmacovigilance in India: Present Scenario and Future Challenges.Drug safety · 2019Article
- The Social Impact of Suspected Adverse Drug Reactions: An analysis of the Canada Vigilance Spontaneous Reporting Database.Drug safety · 2019Article
- Association of adverse drug reaction to anti-tuberculosis medication with quality of life in patients in a tertiary referral hospital.Revista da Sociedade Brasileira de Medicina Tropical · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
contextAdverse drug reactions (ADR) due to antipsychotic therapy have significant impact on a psychiatric patient's quality of life. Few studies have been conducted in India to monitor adverse drug reactions due to antispsychotics and none has been done to determine their impact on quality of life.
aimsThe present study was conducted to monitor ADRs due to antipsychotics and ascertain the impact of ADRs on quality of life. SETTINGS AND
designThis prospective observational study was conducted in the psychiatry outpatients department in New Delhi for 1 year. PATIENTS AND
methodsA total of 224 patients enrolled were followed up for a period of 3 months. ADRs were monitored using the standard form of the Central Drugs Standard Control Organization and causality was determined using the Naranjo algorithm. The WHO Quality of Life BREF (WHOQOL-BREF) scale was used to study the effect of ADR on the quality of life. STATISTICAL ANALYSIS USED: The data were entered and analyzed using the statistical software SPSS 17.0. Unpaired
resultsOf the total 224 patients, 38 adverse drug events occurred. Adverse drug events were mostly with risperidone (10), followed by olanzapine (8) owing to high usage. Majority of the events were classified as probable (34). The occurrence of adverse drug events decreased the scores on physical and psychological domain scores of WHO-QOL BREF at 3 months compared to baseline.
conclusionsThe study provides information on the existing incidence of ADRs in the setup with an established pharmacovigilance center. The nature of ADRs correlates with the prevalence pattern of usage of atypical antipsychotics. Clinicians need to weigh benefit versus the impact on quality of life while prescribing antipsychotics.
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