ArticleScientific reports2017
Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 96 citations in OpenAlex.
- Numerical investigation of ultrasound-induced acoustic streaming and shear stress for blood clot manipulation.Scientific reports · 2026Article
- Study on Ultrasound Transducers With Alternating Current Poled Pb(MgIEEE transactions on ultrasonics · 2026Article
- Self-Sensing with Hollow Cylindrical Transducers for Histotripsy-Enhanced Aspiration Mechanical Thrombectomy Applications.Sensors (Basel, Switzerland) · 2025Article
- Novel Phase Shift Microbubbles, MVT-101, Enhance Sonothrombolysis in a Porcine Model of Deep Vein Thrombosis.Nanotheranostics · 2025Article
- Millisecond-level transient heating and temperature monitoring technique for ultrasound-induced thermal strain imaging.Theranostics · 2025Article
- Magnetic drug-loaded microbubbles for treating lower limb venous thrombosis under controllable rotating magnetic field.Frontiers in bioengineering and biotechnology · 2025Article
- A 9-Fr Endovascular Therapy Transducer With an Acoustic Metamaterial Lens for Rapid Stroke Thrombectomy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- An in vitro comparative study on clot lysis efficiency of urokinase and reteplase with the synergy of ultrasound needle.Heliyon · 2024Article
- Vortex-ultrasound for microbubble-mediated thrombolysis of retracted clots.Applied physics letters · 2023Article
- Miniaturized Stacked Transducer for Intravascular Sonothrombolysis With Internal-Illumination Photoacoustic Imaging Guidance and Clot Characterization.IEEE transactions on bio-medical engineering · 2023Article
- Supervised segmentation for guiding peripheral revascularization with forward-viewing, robotically steered ultrasound guidewire.Medical physics · 2023Article
- The Safety and Efficacy of Ultrasound-Accelerated Catheter-Directed Thrombolysis in Patients with Intermediate-High-Risk Pulmonary Embolism: Bo-NE-Experience.Journal of clinical medicine · 2023Article
- [Ultrasound-accelerated thrombolysis. Initial experience in patients with contraindications to systemic thrombolysis].Revista medica del Instituto Mexicano del Seguro Social · 2023Review
- Magnetic Nanoparticles Mediated Thrombolysis-A Review.IEEE open journal of nanotechnology · 2023Article
- A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis.Research (Washington, D.C.) · 2023Article
- Interventional Microbubble Enhanced Sonothrombolysis on Left Ventricular Assist Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Ultrasound-Guided Intravascular Sonothrombolysis With a Dual Mode Ultrasound Catheter: In Vitro Study.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Deep thrombosis characterization using photoacoustic imaging with intravascular light delivery.Biomedical engineering letters · 2022Article
- Application of magnetically actuated self-clearing catheter for rapid in situ blood clot clearance in hemorrhagic stroke treatment.Nature communications · 2022Article
- Enhanced thrombolysis by endovascular low-frequency ultrasound with bifunctional microbubbles in venous thrombosis:Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the required dose of thrombolytic drugs. We hypothesize that a sub-megahertz, forward-looking ultrasound transducer with an integrated microbubble injection tube is more advantageous for efficient thrombolysis by enhancing cavitation-induced microstreaming than the conventional high-frequency, side-looking, catheter-mounted transducers. We developed custom miniaturized transducers and demonstrated that these transducers are able to generate sufficient pressure to induce cavitation of lipid-shelled microbubble contrast agents. Our technology demonstrates a thrombolysis rate of 0.7 ± 0.15 percent mass loss/min in vitro without any use of thrombolytic drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.