ArticleScientific reports2017
Skin sloughing in susceptible and resistant amphibians regulates infection with a fungal pathogen.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Cutaneous shedding in amphibians causes shifts in bacterial microbiomes.Integrative zoology · 2025Article
- Quantifying intraspecific variation in host resistance and tolerance to a lethal pathogen.The Journal of animal ecology · 2025Article
- Amphibian cellular immune response to chytridiomycosis at metamorphic climax.Immunologic research · 2025Article
- Differential recruitment drives pathogen-mediated competition between species in an amphibian chytridiomycosis system.Ecological applications : a publication of the Ecological Society of America · 2025Article
- Amphibian infection tolerance to chytridiomycosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Signatures of functional bacteriome structure in a tropical direct-developing amphibian species.Animal microbiome · 2022Article
- Microbial Diversity of the Chinese Tiger Frog (Animals : an open access journal from MDPI · 2022Article
- Applied ecoimmunology: using immunological tools to improve conservation efforts in a changing world.Conservation physiology · 2021Article
- The amphibian complement system and chytridiomycosis.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2020Review
- Immunological Aspects of Chytridiomycosis.Journal of fungi (Basel, Switzerland) · 2020Review
- Experimental methodologies can affect pathogenicity of Batrachochytrium salamandrivorans infections.PloS one · 2020Article
- Characteristics of monolayer formationBiofilm · 2019Article
- Phylogenetic investigation of skin sloughing rates in frogs: relationships with skin characteristics and disease-driven declines.Proceedings. Biological sciences · 2019Article
- Body size influences energetic and osmoregulatory costs in frogs infected with Batrachochytrium dendrobatidis.Scientific reports · 2018Article
- Gene expression differs in susceptible and resistant amphibians exposed toRoyal Society open science · 2018Article
- Review of the Amphibian Immune Response to Chytridiomycosis, and Future Directions.Frontiers in immunology · 2018Review
- Frog Skin Innate Immune Defences: Sensing and Surviving Pathogens.Frontiers in immunology · 2018Review
- Defensive coloration is not a reliable indicator of fungal infection in aposematic poison frogs.Behavioral ecology : official journal of the International Society for Behavioral EcologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fungal pathogen Batrachochytrium dendrobatidis (Bd) has been implicated in amphibian population declines globally. Given that Bd infection is limited to the skin in post-metamorphic amphibians, routine skin sloughing may regulate infection. Skin sloughing has been shown to reduce the number of cultivatable microbes on amphibian skin, and Bd infection increases skin sloughing rates at high loads. However, it is unclear whether species specific differences in skin sloughing patterns could regulate Bd population growth on the skin, and influence subsequent infection dynamics. We exposed five Australian frog species to Bd, and monitored sloughing rates and infection loads over time. Sloughing reduced Bd load on the ventral skin surface, in all five species, despite wide variation in susceptibility to disease. In the least susceptible species, an increase in sloughing rate occurred at lower infection loads, and sloughing reduced Bd load up to 100%, leading to infection clearance. Conversely, the drop in Bd load with sloughing was only temporary in the more susceptible species. These findings indicate that the ability of sloughing to act as an effective immune defence is species specific, and they have implications for understanding the pattern of Bd population growth on individual hosts, as well as population-level effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.