ArticleScientific reports2017
Comparative genomics and transcriptomics of Escherichia coli isolates carrying virulence factors of both enteropathogenic and enterotoxigenic E. coli.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Virulome Landscape of Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2026Article
- Imported Retail Beef and Chicken Meat Products Serve as Reservoirs for Emerging Antibiotic-Resistant Pathotypes of Escherichia coli in Pristine Areas Free From Agricultural Activity.MicrobiologyOpen · 2026Article
- Complete genomes of hybridMicrobiology resource announcements · 2025Article
- Exploring Virulence Characteristics of ClinicalMicroorganisms · 2025Article
- Virulence and Antibiotic Resistance of aEPEC/STECPathogens (Basel, Switzerland) · 2025Article
- Hybrid strains of enterotoxigenic/Shiga toxin-producingJournal of medical microbiology · 2025Article
- Article
- Direct and macrophage stimulation mediated effects of active, inactive, and cell-free supernatant forms of Akkermansia muciniphila and Faecalibacterium duncaniae on hepcidin gene expression in HepG2 cells.Archives of microbiology · 2024Article
- Application of a Novel Proteomic Microarray Reveals High Exposure to DiarrhoeagenicMicroorganisms · 2024Article
- Article
- Molecular Characterization of Hetero-Pathogenic and DiarrheagenicPathogens (Basel, Switzerland) · 2023Article
- Characteristics of Shiga Toxin-ProducingToxins · 2023Article
- Prevalence and Antimicrobial Resistance Profile of DiarrheagenicAntibiotics (Basel, Switzerland) · 2023Article
- Molecular and Genomic Analysis of the Virulence Factors and Potential Transmission of Hybrid Enteropathogenic and EnterotoxigenicInternational journal of molecular sciences · 2023Article
- Genomic diversity of non-diarrheagenic fecal Escherichia coli from children in sub-Saharan Africa and south Asia and their relatedness to diarrheagenic E. coli.Nature communications · 2023Article
- The emergence of the tetrathionate reductase operon in the Escherichia coli/Shigella pan-genome.MicrobiologyOpen · 2022Article
- Genomics and pathotypes of the many faces of Escherichia coli.FEMS microbiology reviews · 2022Article
- Prevalence, Antimicrobial Resistance, and Whole Genome Sequencing Analysis of Shiga Toxin-ProducingToxins · 2022Article
- Panomics to decode virulence and fitness in Gram-negative bacteria.Frontiers in cellular and infection microbiology · 2022Article
- Occurrence of Hybrid DiarrhoeagenicMicroorganisms · 2021Article
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7 authors.
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Abstract
Escherichia coli that are capable of causing human disease are often classified into pathogenic variants (pathovars) based on their virulence gene content. However, disease-associated hybrid E. coli, containing unique combinations of multiple canonical virulence factors have also been described. Such was the case of the E. coli O104:H4 outbreak in 2011, which caused significant morbidity and mortality. Among the pathovars of diarrheagenic E. coli that cause significant human disease are the enteropathogenic E. coli (EPEC) and enterotoxigenic E. coli (ETEC). In the current study we use comparative genomics, transcriptomics, and functional studies to characterize isolates that contain virulence factors of both EPEC and ETEC. Based on phylogenomic analysis, these hybrid isolates are more genomically-related to EPEC, but appear to have acquired ETEC virulence genes. Global transcriptional analysis using RNA sequencing, demonstrated that the EPEC and ETEC virulence genes of these hybrid isolates were differentially-expressed under virulence-inducing laboratory conditions, similar to reference isolates. Immunoblot assays further verified that the virulence gene products were produced and that the T3SS effector EspB of EPEC, and heat-labile toxin of ETEC were secreted. These findings document the existence and virulence potential of an E. coli pathovar hybrid that blurs the distinction between E. coli pathovars.
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