ArticleProceedings. Biological sciences2017
Antagonistically pleiotropic allele increases lifespan and late-life reproduction at the cost of early-life reproduction and individual fitness.
Article in Proceedings. Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Strong inhibition of insulin/IGF-1 signaling in early-mid adulthood compresses morbidity, but in later life accelerates aging.bioRxiv : the preprint server for biology · 2026Article
- From manual counting to YOLO: Using computer vision to automate large-scale fecundity assays in C. elegans.PloS one · 2026Article
- Variable stressor exposure shapes fitness within and across generations.Scientific reports · 2025Article
- Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology.Genetics · 2024Review
- Pleiotropy, epistasis and the genetic architecture of quantitative traits.Nature reviews. Genetics · 2024Review
- Microbes are potential key players in the evolution of life histories and aging inEcology and evolution · 2023Article
- Genetic and social contributions to sex differences in lifespan in Drosophila serrata.Journal of evolutionary biology · 2022Article
- Lifespan prolonging mechanisms and insulin upregulation without fat accumulation in long-lived reproductives of a higher termite.Communications biology · 2022Article
- Alternative models for transgenerational epigenetic inheritance: Molecular psychiatry beyond mice and man.World journal of psychiatry · 2021Review
- Ageing as "early-life inertia": Disentangling life-history trade-offs along a lifetime of an individual.Evolution letters · 2021Article
- Cost-free lifespan extension via optimization of gene expression in adulthood aligns with the developmental theory of ageing.Proceedings. Biological sciences · 2021Article
- Aging modulated by the Drosophila insulin receptor through distinct structure-defined mechanisms.Genetics · 2021Article
- Observational
- Evolution of ageing as a tangle of trade-offs: energy versus function.Proceedings. Biological sciences · 2019Article
- Live fast, don't die young: Survival-reproduction trade-offs in long-lived income breeders.The Journal of animal ecology · 2019Article
- Experimentally reduced insulin/IGF-1 signaling in adulthood extends lifespan of parents and improves Darwinian fitness of their offspring.Evolution letters · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evolutionary theory of ageing maintains that increased allocation to early-life reproduction results in reduced somatic maintenance, which is predicted to compromise longevity and late-life reproduction. This prediction has been challenged by the discovery of long-lived mutants with no loss of fecundity. The first such long-lived mutant was found in the nematode worm
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.