ReviewThe Journal of biological chemistry2017
Cytosolic iron chaperones: Proteins delivering iron cofactors in the cytosol of mammalian cells.
Review in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 116 citations in OpenAlex.
- RNA binding proteinScience advances · 2026Article
- Histological and Proteomic Approaches to Assessing the Adrenal Stress Response in Common Dolphins (Animals : an open access journal from MDPI · 2025Article
- PCBP2 in gastrointestinal cancers: fundamental mechanism and clinical potential.Journal of molecular medicine (Berlin, Germany) · 2025Review
- The thioredoxin-like and one glutaredoxin domain are required to rescue the iron-starvation phenotype of HeLa GLRX3 knock out cells.FEBS letters · 2025Article
- Why cells need iron: a compendium of iron utilisation.Trends in endocrinology and metabolism: TEM · 2024Review
- PHD2 enzyme is an intracellular manganese sensor that initiates the homeostatic response against elevated manganese.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Exogenous Iron Induces Mitochondrial Lipid Peroxidation, Lipofuscin Accumulation, and Ferroptosis in H9c2 Cardiomyocytes.Biomolecules · 2024Article
- Iron Absorption: Molecular and Pathophysiological Aspects.Metabolites · 2024Review
- Iron Homeostasis inBiology · 2023Review
- Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity.Nucleic acids research · 2023Article
- Promotion of ferroptosis in head and neck cancer with divalent metal transporter 1 inhibition or salinomycin.Human cell · 2023Article
- Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney.Nature reviews. Nephrology · 2023Review
- The Interplay between Intracellular Iron Homeostasis and Neuroinflammation in Neurodegenerative Diseases.Antioxidants (Basel, Switzerland) · 2023Review
- Anti-Ferroptotic Effects of Nrf2: Beyond the Antioxidant Response.Molecules and cells · 2023Review
- Iron Homeostasis in Insects.Annual review of entomology · 2023Review
- The role of ferroptosis in intervertebral disc degeneration.Frontiers in cell and developmental biology · 2023Review
- Mapping of the QTLs governing grain micronutrients and thousand kernel weight in wheat (Frontiers in nutrition · 2023Article
- Acaricidal Potential and Ecotoxicity of Metallic Nano-Pesticides Used against the Major Life Stages ofLife (Basel, Switzerland) · 2022Article
- DMT1 Protects Macrophages fromInternational journal of molecular sciences · 2022Article
- Iron Mobilization from Ferritin in Yeast Cell Lysate and Physiological Implications.International journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Eukaryotic cells contain hundreds of metalloproteins that are supported by intracellular systems coordinating the uptake and distribution of metal cofactors. Iron cofactors include heme, iron-sulfur clusters, and simple iron ions. Poly(rC)-binding proteins are multifunctional adaptors that serve as iron ion chaperones in the cytosolic/nuclear compartment, binding iron at import and delivering it to enzymes, for storage (ferritin) and export (ferroportin). Ferritin iron is mobilized by autophagy through the cargo receptor, nuclear co-activator 4. The monothiol glutaredoxin Glrx3 and BolA2 function as a [2Fe-2S] chaperone complex. These proteins form a core system of cytosolic iron cofactor chaperones in mammalian cells.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.