ArticleNeurology2017
Insulin resistance among obese middle-aged is associated with decreased cerebrovascular reactivity.
Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Sex-related differences in the prevalence of cognitive impairment among overweight and obese adults with type 2 diabetes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Trial
- Sex comparison of cerebrovascular reactivity to COJournal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Cerebrovascular Function in Women With Polycystic Ovary Syndrome: A Pilot Multi-Parameter Magnetic Resonance Imaging Study.Clinical endocrinology · 2026Article
- Obesity as a catalyst for neurodegeneration.Nature metabolism · 2026Review
- Insulin Resistance Is Not Associated With Perceived Exertion or Cerebral Oxygenation During Exercise in Women.Translational sports medicine · 2026Article
- Insulin resistance in cerebral small vessel disease: a mini review.Frontiers in neuroscience · 2026Review
- Smartphone-Based Physical Activity Program to Reduce "Chemo-Brain" Symptoms and Improve Health in Cancer Survivors With and Without Type 2 Diabetes: Protocol for a Single-Arm Pre-Post Pilot Trial.JMIR research protocols · 2025Article
- Western diet since adolescence impairs brain functional hyperemia at adulthood in mice: rescue by a balanced ω-3:ω-6 polyunsaturated fatty acids ratio.International journal of obesity (2005) · 2025Article
- Low Serum Asprosin Levels in Fibromyalgia Syndrome: Insights from a Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- Exploring the TyG Index and the Homeostasis Model Assessment of Insulin Resistance as Insulin Resistance Markers: Implications for Fibromyalgia Management and Understanding-A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Paediatric obesity and metabolic syndrome associations with cognition and the brain in youth: Current evidence and future directions.Pediatric obesity · 2023Review
- A Study on the Pathogenesis of Vascular Cognitive Impairment and Dementia: The Chronic Cerebral Hypoperfusion Hypothesis.Journal of clinical medicine · 2022Review
- Higher body mass index is associated with worse hippocampal vasoreactivity to carbon dioxide.Frontiers in aging neuroscience · 2022Article
- Cerebrovascular Function, Vascular Risk, and Lifestyle Patterns in Resistant Hypertension.Journal of Alzheimer's disease : JAD · 2022Article
- Telmisartan use and risk of dementia in type 2 diabetes patients with hypertension: A population-based cohort study.PLoS medicine · 2021Article
- Insulin Resistance is Associated with Central Pain in Patients with Fibromyalgia.Pain physician · 2021Observational
- Intranasal Insulin for Alzheimer's Disease.CNS drugs · 2021Review
- Gut Microbiome, Inflammation, and Cerebrovascular Function: Link Between Obesity and Cognition.Frontiers in neuroscience · 2021Review
- Intracranial hemodynamic relationships in patients with cerebral small vessel disease.Neurology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo evaluate differences in cerebrovascular reactivity (CVR) to mild hypercapnia in obese/overweight individuals with and without insulin resistance (IR) compared to comparable lean controls.
methodsA total of 60 cognitively normal participants (20 lean controls and 24 obese/overweight individuals with and 16 without IR) were evaluated using a high spatial resolution arterial spin labeling MRI technique at rest and during mild hypercapnia. We analyzed group differences in CVR in cerebral cortex and ascertained the relationships between CVR, IR, and body mass index (BMI).
resultsObese/overweight participants with and without IR had significantly lower CVR to hypercapnia than lean controls after controlling for age, sex, and the presence of hypertension (
conclusionsIR is associated with impaired CVR; the relationship appears to be driven by the degree of IR and not by obesity. These rarely reported results suggest that early forms of cerebrovascular dysfunction exist among obese middle-aged individuals with significant IR but without type 2 diabetes mellitus. These functional vascular abnormalities may help explain the associations among IR, diabetes, and dementia, and suggest that interventions aiming to improve IR or CVR may help prevent cognitive decline later in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.