ArticleJournal of neurophysiology2017
Comparison of the VTA and LC response to methylphenidate: a concomitant behavioral and neuronal study of adolescent male rats.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Emotional and sensory dysregulation as a possible missing link in attention deficit hyperactivity disorder: A review.Frontiers in behavioral neuroscience · 2023Review
- Adolescent rats respond differently to methylphenidate as compared to adult rats- concomitant VTA neuronal and behavioral Recordings.Brain research bulletin · 2022Article
- Immunotherapy as a treatment to confront the ongoing opioid epidemic- A review.Journal of cellular and molecular immunology · 2022Article
- Dopaminergic and noradrenergic modulation of stress-induced alterations in brain activation associated with goal-directed behaviour.Journal of psychopharmacology (Oxford, England) · 2021Article
- Glutaminergic signaling in the caudate nucleus is required for behavioral sensitization to methylphenidate.Pharmacology, biochemistry, and behavior · 2019Article
- Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats.Brain and behavior · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Methylphenidate (MPD), also known as Ritalin, is a psychostimulant used to treat attention deficit hyperactivity disorder. However, it is increasingly being misused by normal adolescents for recreation and academic advantage. Therefore, it is important to elucidate the behavioral and neurophysiological effects of MPD in normal subjects. MPD inhibits the reuptake of catecholamines, mainly found in the ventral tegmental area (VTA) and locus coeruleus (LC). The VTA and LC normally mediate attention, motivation, and drug reward behaviors. Selective neuronal connections between the VTA and LC have been identified implicating regular interaction between the structures. The objective of this study was to compare the neuronal responses of the VTA and LC to MPD in normal adolescent rats. Animals were implanted with permanent electrodes in the VTA and LC, and neuronal units were recorded following acute and repetitive (chronic) saline or 0.6, 2.5, or 10.0 mg/kg MPD exposure. Animals displayed either behavioral sensitization or tolerance to all three doses of MPD. Acute MPD exposure elicited excitation in the majority of all VTA and LC units. Chronic MPD exposure elicited a further increase in VTA and LC neuronal activity in animals exhibiting behavioral sensitization and an attenuation in VTA and LC neuronal activity in animals exhibiting behavioral tolerance, demonstrating neurophysiological sensitization and tolerance, respectively. The similar pattern in VTA and LC unit activity suggests that the two structures are linked in their response to MPD. These results may help determine the exact mechanism of action of MPD, resulting in optimized treatment of patients.
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