Evidence map›Paper›PMID 28615316›Full record

ReviewPhysiology (Bethesda, Md.)2017

ORAI Calcium Channels.

Mohamed Trebak, James W Putney

Open access · bronzeAbstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 87 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Divergent Functions of Rap1A and Rap1B in Endothelial Biology and Disease.International journal of molecular sciences · 2025
    Review
  9. Article
  10. Review
  11. Regulation of Yeast Cytokinesis by Calcium.Journal of fungi (Basel, Switzerland) · 2025
    Review
  12. Article
  13. Rap1 Brings the A Game to Control Lung Endothelium.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. CaPhysiological reviews · 2024
    Review
  18. STIM1 in tumor cell death: angel or devil?Cell death discovery · 2023
    Review
  19. A multiple-oscillator mechanism underlies antigen-induced CaThe Journal of biological chemistry · 2023
    Article
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Mohamed TrebakThe Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania; and mtrebak@psu.edu.
James W PutneyThe National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
National Institutes of Health · USPennsylvania State University · US

Funding

CAPACITATIVE CALCIUM ENTRYZ01ES090087 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI PUTNEY, JAMES W · 1997 to 2008
$5.2M
Receptor-regulated Ca2+ Entry Pathways in Smooth MuscleR01HL097111 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2010 to 2019
$3.7M
Leukotriene C4 and STIM/Orai channels in airway smooth muscle remodelingR01HL123364 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2014 to 2017
$1.5M
Genes and miRNAs controlled by ORAI3 in cardiovascular remodelingR21AG050072 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEBECHE, DJAMEL, TREBAK, MOHAMED · 2016 to 2017
$471k
Intramural NIH HHS Z01 ES090087NHLBI NIH HHS R01 HL097111NHLBI NIH HHS R01 HL123364NIA NIH HHS R21 AG050072
6 · The paper itself

Abstract

In this review article, we discuss the different gene products and translational variants of ORAI proteins and their contribution to the makeup of different native calcium-conducting channels with distinct compositions and modes of activation. We also review the different modes of regulation of these distinct calcium channels and their impact on downstream cellular signaling controlling important physiological functions.

Indexed as

AnimalsCalciumCalcium ChannelsCalcium SignalingHumansCalciumCalcium Channels

Identifiers

PMID28615316
PMCPMC5545608
OpenAlexW2625835005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.