Evidence map›Paper›PMID 28615301›Full record

ArticleGut2017

Judith-Mira Pohl, Sebastian Gutweiler, Stephanie Thiebes, Julia K Volke, Ludger Klein-Hitpass, Denise Zwanziger, Matthias Gunzer, Steffen Jung, William W Agace, Christian Kurts and 1 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Gut, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Emerging roles of MITF as a crucial regulator of immunity.Experimental & molecular medicine · 2024
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. The implication of gut microbiota in recovery from gastrointestinal surgery.Frontiers in cellular and infection microbiology · 2023
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. SSAT State-of-the-Art Conference: Advancements in the Microbiome.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Judith-Mira PohlInstitute of Experimental Immunology and Imaging, University Duisburg-Essen and University Hospital Essen, Essen, Germany.
Sebastian GutweilerInstitute of Experimental Immunology and Imaging, University Duisburg-Essen and University Hospital Essen, Essen, Germany.
Stephanie ThiebesInstitute of Experimental Immunology and Imaging, University Duisburg-Essen and University Hospital Essen, Essen, Germany.
Julia K VolkeInstitute of Experimental Immunology and Imaging, University Duisburg-Essen and University Hospital Essen, Essen, Germany.
Ludger Klein-HitpassInstitute of Cell Biology (Cancer Research), University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Denise ZwanzigerDepartment of Endocrinology and Metabolism, Division of Laboratory Research, University Hospital Essen, Essen, Germany.
Matthias GunzerInstitute of Experimental Immunology and Imaging, University Duisburg-Essen and University Hospital Essen, Essen, Germany.
Steffen JungDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel.
William W AgaceImmunology Section, Lund University, Lund, Sweden.
Christian KurtsInstitute of Experimental Immunology, Rheinische Friedrich-Wilhelms University, Bonn, Germany.
Daniel Robert EngelInstitute of Experimental Immunology and Imaging, University Duisburg-Essen and University Hospital Essen, Essen, Germany.ORCID 0000-0001-7301-353X
University of Duisburg-Essen · DEEssen University Hospital · DEUniversity of Bonn · DELund University · SEWeizmann Institute of Science · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePostoperative ileus (POI), the most frequent complication after intestinal surgery, depends on dendritic cells (DCs) and macrophages. Here, we have investigated the mechanism that activates these cells and the contribution of the intestinal microbiota for POI induction.

designPOI was induced by manipulating the intestine of mice, which selectively lack DCs, monocytes or macrophages. The disease severity in the small and large intestine was analysed by determining the distribution of orally applied fluorescein isothiocyanate-dextran and by measuring the excretion time of a retrogradely inserted glass ball. The impact of the microbiota on intestinal peristalsis was evaluated after oral antibiotic treatment.

resultsWe found that

conclusionsOur findings reveal that CD103

Indexed as

Gastrointestinal MicrobiomeMacrophage ActivationAnimalsAntigens, CDCD11b AntigenDendritic CellsDisease Models, AnimalGastrointestinal TransitIleusIntegrin alpha ChainsMiceMice, TransgenicMonocytesPeristalsisPostoperative Complicationsalpha E integrinsAntigens, CDCD11b AntigenIntegrin alpha ChainsImmunityIntestinal Monocytes and Macrophages, Dendritic cellsMicrobiotaPostoperative Ileus

Identifiers

PMID28615301
PMCPMC5749346
OpenAlexW2690953659

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.