Evidence map›Paper›PMID 28615271›Full record

Trial reportBMJ open2017

Cost-effectiveness of a randomised trial of physical activity in Alzheimer's disease: a secondary analysis exploring patient and proxy-reported health-related quality of life measures in Denmark.

Elizaveta Sopina, Jan Sørensen, Nina Beyer, Steen Gregers Hasselbalch, Gunhild Waldemar

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase IIIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01681602 (Preserving Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease), which is not on this map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
14.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01681602 phase3completednot on this map

Preserving Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise

TypeinterventionalSponsorRigshospitalet, DenmarkRan2012 to 2014Enrolled200ConditionsAlzheimer DiseaseArmsAerobic exercise
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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  15. Health-related quality of life in people with advanced dementia: a comparison of EQ-5D-5L and QUALID instruments.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Elizaveta SopinaCenter of Health Economic Research, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Jan SørensenCenter of Health Economic Research, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Nina BeyerDepartment of Physical and Occupational Therapyand Institute of Sports Medicine, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.
Steen Gregers HasselbalchDanish Dementia Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Gunhild WaldemarDanish Dementia Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Rigshospitalet · DKRoyal College of Surgeons in Ireland · IEUniversity of Copenhagen · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo explore the cost-effectiveness of a supervised moderate-to-high intensity aerobic exercise programme in people diagnosed with Alzheimer's disease (AD) and estimate incremental cost-effectiveness ratios (ICER) using participant-reported and proxy-reported measures of health-related quality of life (HRQoL)

designA cost-effectiveness analysis of economic and HRQoL data from a randomised trial delivered over 16 weeks.

settingMemory clinics in Denmark.

participants200 individuals with mild AD aged 50-90 years gave informed consent to participate in the study. Participants were randomised to control or intervention group.

interventionsControl group received treatment as usual. The intervention group performed 1 hour of supervised moderate-to-high intensity aerobic exercise three times weekly for 16 weeks. PRIMARY AND SECONDARY OUTCOMES MEASURES: Different physical, functional and health measures were obtained at inclusion (baseline) and 4 and 16 weeks after. HRQoL (EuroQol-5 Dimensions-5 Levels/EQ-Visual Analogue Scale) was reported by the participants and the primary caregivers as proxy respondents. Differences in HRQOL as reported by the participant and caregiver were explored as were different values of caregiver time with respite from care tasks.

resultsThe intervention cost was estimated at €608 and €496 per participant, with and without transport cost, respectively. Participants and caregivers in the intervention group reported a small, positive non-significant improvement in EQ-5D-5L and EQ-VAS after 16 weeks. The ICER was estimated at €72 000/quality-adjusted life year using participant-reported outcomes and €87000 using caregiver-reported outcomes.

conclusionsThe findings suggest that the exercise intervention is unlikely to be cost-effective within the commonly applied threshold values. The cost of the intervention might be offset by potential savings from reduction in use of health and social care. TRIAL REGISTRATION NUMBER: https://clinicaltrials.gov/ct2/show/NCT01681602.

Indexed as

ExerciseQuality of LifeAgedAged, 80 and overAlzheimer DiseaseCaregiversCost-Benefit AnalysisDenmarkFemaleHumansLinear ModelsLogistic ModelsMaleMiddle AgedPain MeasurementPsychiatric Status Rating Scalesalzheimer’s diseasecaregivercost-effectivenessdenmarkquality of life measurement

Identifiers

PMID28615271
PMCPMC5734413
OpenAlexW2625179913

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.